Stabilin Receptors: Role as Phosphatidylserine Receptors

Seung Yoon Park, In-San Kim

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Phosphatidylserine is a membrane phospholipid that is localized to the inner leaflet of the plasma membrane. Phosphatidylserine externalization to the outer leaflet of the plasma membrane is an important signal for various physiological processes, including apoptosis, platelet activation, cell fusion, lymphocyte activation, and regenerative axonal fusion. Stabilin-1 and stabilin-2 are membrane receptors that recognize phosphatidylserine on the cell surface. Here, we discuss the functions of Stabilin-1 and stabilin-2 as phosphatidylserine receptors in apoptotic cell clearance (efferocytosis) and cell fusion, and their ligand-recognition and signaling pathways.

Original languageEnglish
JournalBiomolecules
Volume9
Issue number8
DOIs
Publication statusPublished - 2019 Aug 20

Fingerprint

Cell Fusion
Phosphatidylserines
Fusion reactions
Cell Membrane
Cell membranes
Physiological Phenomena
Membranes
Platelet Activation
Lymphocyte Activation
Chemical activation
Phospholipids
Lymphocytes
Apoptosis
Platelets
Ligands
Cells
phosphatidylserine receptor

Keywords

  • efferocytosis
  • fusion
  • phosphatidylserine
  • stabilin-1
  • stabilin-2

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

Cite this

Stabilin Receptors : Role as Phosphatidylserine Receptors. / Park, Seung Yoon; Kim, In-San.

In: Biomolecules, Vol. 9, No. 8, 20.08.2019.

Research output: Contribution to journalReview article

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AB - Phosphatidylserine is a membrane phospholipid that is localized to the inner leaflet of the plasma membrane. Phosphatidylserine externalization to the outer leaflet of the plasma membrane is an important signal for various physiological processes, including apoptosis, platelet activation, cell fusion, lymphocyte activation, and regenerative axonal fusion. Stabilin-1 and stabilin-2 are membrane receptors that recognize phosphatidylserine on the cell surface. Here, we discuss the functions of Stabilin-1 and stabilin-2 as phosphatidylserine receptors in apoptotic cell clearance (efferocytosis) and cell fusion, and their ligand-recognition and signaling pathways.

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