Standard and double-dose intravenous proton pump inhibitor injections for prevention of bleeding after endoscopic resection

Research output: Contribution to journalArticle

Abstract

Background and Aim: Endoscopic resection is commonly used to remove gastric neoplasms. However, effective dosing or scheduling of proton pump inhibitors for the prevention of delayed bleeding after endoscopic resection remains unclear. Methods: One hundred sixty-six patients with gastric adenoma or early gastric cancer were enrolled. After an endoscopic procedure, each subject was randomly assigned to 40 mg every 24 h (standard dose group) or 40 mg every 12 h (double-dose group) of intravenous pantoprazole for 48 h. Second-look endoscopy was performed on day 2 after endoscopic resection to compare signs of rebleeding and ulcer status between the two groups. Result: Eighty-one patients of the standard dose group and 81 of the double-dose group were analyzed. There were no significant differences in the incidence of delayed bleeding events (1.3% vs 6.2%, P = 0.21) and bleeding ulcer at the second-look endoscopy (6.2% vs 3.9%, P = 0.69) between standard and double-dose groups. There were no other significant variables associated with delayed bleeding or bleeding ulcer on second-look endoscopy. Conclusions: Intravenous pantoprazole 40 mg every 24 h or 12 h for 2 days after endoscopic resection was equally effective for the prevention of delayed bleeding.

Original languageEnglish
Pages (from-to)778-781
Number of pages4
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume32
Issue number4
DOIs
Publication statusPublished - 2017 Apr 1

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Proton Pump Inhibitors
Hemorrhage
Injections
Endoscopy
Ulcer
Stomach Neoplasms
Adenoma
Stomach
Incidence

Keywords

  • endoscopic resection
  • iatrogenic gastric ulcer
  • proton pump inhibitor

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

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title = "Standard and double-dose intravenous proton pump inhibitor injections for prevention of bleeding after endoscopic resection",
abstract = "Background and Aim: Endoscopic resection is commonly used to remove gastric neoplasms. However, effective dosing or scheduling of proton pump inhibitors for the prevention of delayed bleeding after endoscopic resection remains unclear. Methods: One hundred sixty-six patients with gastric adenoma or early gastric cancer were enrolled. After an endoscopic procedure, each subject was randomly assigned to 40 mg every 24 h (standard dose group) or 40 mg every 12 h (double-dose group) of intravenous pantoprazole for 48 h. Second-look endoscopy was performed on day 2 after endoscopic resection to compare signs of rebleeding and ulcer status between the two groups. Result: Eighty-one patients of the standard dose group and 81 of the double-dose group were analyzed. There were no significant differences in the incidence of delayed bleeding events (1.3{\%} vs 6.2{\%}, P = 0.21) and bleeding ulcer at the second-look endoscopy (6.2{\%} vs 3.9{\%}, P = 0.69) between standard and double-dose groups. There were no other significant variables associated with delayed bleeding or bleeding ulcer on second-look endoscopy. Conclusions: Intravenous pantoprazole 40 mg every 24 h or 12 h for 2 days after endoscopic resection was equally effective for the prevention of delayed bleeding.",
keywords = "endoscopic resection, iatrogenic gastric ulcer, proton pump inhibitor",
author = "Jung, {Sung Woo} and Kim, {Seung Young} and Choe, {Jung Wan} and Hyun, {Jong Jin} and Jung, {Young Kul} and Koo, {Ja Seol} and Yim, {Hyung Joon} and Lee, {Sang Woo}",
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T1 - Standard and double-dose intravenous proton pump inhibitor injections for prevention of bleeding after endoscopic resection

AU - Jung, Sung Woo

AU - Kim, Seung Young

AU - Choe, Jung Wan

AU - Hyun, Jong Jin

AU - Jung, Young Kul

AU - Koo, Ja Seol

AU - Yim, Hyung Joon

AU - Lee, Sang Woo

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N2 - Background and Aim: Endoscopic resection is commonly used to remove gastric neoplasms. However, effective dosing or scheduling of proton pump inhibitors for the prevention of delayed bleeding after endoscopic resection remains unclear. Methods: One hundred sixty-six patients with gastric adenoma or early gastric cancer were enrolled. After an endoscopic procedure, each subject was randomly assigned to 40 mg every 24 h (standard dose group) or 40 mg every 12 h (double-dose group) of intravenous pantoprazole for 48 h. Second-look endoscopy was performed on day 2 after endoscopic resection to compare signs of rebleeding and ulcer status between the two groups. Result: Eighty-one patients of the standard dose group and 81 of the double-dose group were analyzed. There were no significant differences in the incidence of delayed bleeding events (1.3% vs 6.2%, P = 0.21) and bleeding ulcer at the second-look endoscopy (6.2% vs 3.9%, P = 0.69) between standard and double-dose groups. There were no other significant variables associated with delayed bleeding or bleeding ulcer on second-look endoscopy. Conclusions: Intravenous pantoprazole 40 mg every 24 h or 12 h for 2 days after endoscopic resection was equally effective for the prevention of delayed bleeding.

AB - Background and Aim: Endoscopic resection is commonly used to remove gastric neoplasms. However, effective dosing or scheduling of proton pump inhibitors for the prevention of delayed bleeding after endoscopic resection remains unclear. Methods: One hundred sixty-six patients with gastric adenoma or early gastric cancer were enrolled. After an endoscopic procedure, each subject was randomly assigned to 40 mg every 24 h (standard dose group) or 40 mg every 12 h (double-dose group) of intravenous pantoprazole for 48 h. Second-look endoscopy was performed on day 2 after endoscopic resection to compare signs of rebleeding and ulcer status between the two groups. Result: Eighty-one patients of the standard dose group and 81 of the double-dose group were analyzed. There were no significant differences in the incidence of delayed bleeding events (1.3% vs 6.2%, P = 0.21) and bleeding ulcer at the second-look endoscopy (6.2% vs 3.9%, P = 0.69) between standard and double-dose groups. There were no other significant variables associated with delayed bleeding or bleeding ulcer on second-look endoscopy. Conclusions: Intravenous pantoprazole 40 mg every 24 h or 12 h for 2 days after endoscopic resection was equally effective for the prevention of delayed bleeding.

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