Standard versus high loading doses of clopidogrel in Asian ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: Insights from the Korea acute myocardial infarction registry

Cheol Ung Choi, Seung-Woon Rha, Dong Joo Oh, Kanhaiya L. Poddar, Jin Oh Na, Jin Won Kim, Hong Euy Lim, Eung Ju Kim, Chang Gyu Park, Hong Seog Seo, Taek Jong Hong, Jong Seon Park, Young Jo Kim, Seung Ho Hur, In Whan Seong, Jei Keon Chae, Myeong Chan Cho, Jang Ho Bae, Dong Hoon Choi, Yang Soo JangIn Ho Chae, Hyo Soo Kim, Chong Jin Kim, Jung Han Yoon, Tae Hoon Ahn, Seung Jea Tahk, Wook Sung Chung, Ki Bae Seung, Shung Chall Chae, Seung Jung Park, Young Keun Ahn, Myung Ho Jeong

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: The optimal loading dose of clopidogrel in Asian patients with ST-segment elevation myocardial infarction (STEMI) has not been fully investigated. We compared bleeding, vascular complications, and midterm outcomes of a 300-mg versus a 600-mg loading dose of clopidogrel in a large series of Korean patients with STEMI undergoing primary percutaneous coronary intervention (PCI). Methods: A total of 2,664 STEMI patients (age 61.96 ± 11.91 years, men 70.4%) who underwent primary PCI were enrolled in this study. The patients were divided into a standard loading dose group (300 mg; n = 1,447 patients) and a high loading dose group (600 mg; n = 1,217 patients). Bleeding and vascular complications, and in-hospital and clinical outcomes up to 12 months were compared between the 2 groups. Results: In-hospital bleeding and vascular complications were similar between the 2 groups. There were no differences in bleeding and vascular complications and in 1- and 12-month clinical outcomes, including mortality, myocardial infarction, repeated PCI, and major adverse cardiac events, between the 2 groups. These findings were consistent even after the propensity score-matched analysis. Conclusions: The standard loading dose of clopidogrel may be as safe and similarly effective as the high loading dose in Asian STEMI patients undergoing primary PCI.

Original languageEnglish
JournalAmerican Heart Journal
Volume161
Issue number2
DOIs
Publication statusPublished - 2011 Feb 1

Fingerprint

clopidogrel
Percutaneous Coronary Intervention
Korea
Registries
Myocardial Infarction
Blood Vessels
Hemorrhage
Propensity Score
ST Elevation Myocardial Infarction

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Standard versus high loading doses of clopidogrel in Asian ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention : Insights from the Korea acute myocardial infarction registry. / Choi, Cheol Ung; Rha, Seung-Woon; Oh, Dong Joo; Poddar, Kanhaiya L.; Na, Jin Oh; Kim, Jin Won; Lim, Hong Euy; Kim, Eung Ju; Park, Chang Gyu; Seo, Hong Seog; Hong, Taek Jong; Park, Jong Seon; Kim, Young Jo; Hur, Seung Ho; Seong, In Whan; Chae, Jei Keon; Cho, Myeong Chan; Bae, Jang Ho; Choi, Dong Hoon; Jang, Yang Soo; Chae, In Ho; Kim, Hyo Soo; Kim, Chong Jin; Yoon, Jung Han; Ahn, Tae Hoon; Tahk, Seung Jea; Chung, Wook Sung; Seung, Ki Bae; Chae, Shung Chall; Park, Seung Jung; Ahn, Young Keun; Jeong, Myung Ho.

In: American Heart Journal, Vol. 161, No. 2, 01.02.2011.

Research output: Contribution to journalArticle

Choi, CU, Rha, S-W, Oh, DJ, Poddar, KL, Na, JO, Kim, JW, Lim, HE, Kim, EJ, Park, CG, Seo, HS, Hong, TJ, Park, JS, Kim, YJ, Hur, SH, Seong, IW, Chae, JK, Cho, MC, Bae, JH, Choi, DH, Jang, YS, Chae, IH, Kim, HS, Kim, CJ, Yoon, JH, Ahn, TH, Tahk, SJ, Chung, WS, Seung, KB, Chae, SC, Park, SJ, Ahn, YK & Jeong, MH 2011, 'Standard versus high loading doses of clopidogrel in Asian ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: Insights from the Korea acute myocardial infarction registry', American Heart Journal, vol. 161, no. 2. https://doi.org/10.1016/j.ahj.2010.10.031
Choi, Cheol Ung ; Rha, Seung-Woon ; Oh, Dong Joo ; Poddar, Kanhaiya L. ; Na, Jin Oh ; Kim, Jin Won ; Lim, Hong Euy ; Kim, Eung Ju ; Park, Chang Gyu ; Seo, Hong Seog ; Hong, Taek Jong ; Park, Jong Seon ; Kim, Young Jo ; Hur, Seung Ho ; Seong, In Whan ; Chae, Jei Keon ; Cho, Myeong Chan ; Bae, Jang Ho ; Choi, Dong Hoon ; Jang, Yang Soo ; Chae, In Ho ; Kim, Hyo Soo ; Kim, Chong Jin ; Yoon, Jung Han ; Ahn, Tae Hoon ; Tahk, Seung Jea ; Chung, Wook Sung ; Seung, Ki Bae ; Chae, Shung Chall ; Park, Seung Jung ; Ahn, Young Keun ; Jeong, Myung Ho. / Standard versus high loading doses of clopidogrel in Asian ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention : Insights from the Korea acute myocardial infarction registry. In: American Heart Journal. 2011 ; Vol. 161, No. 2.
@article{e592f109977d4b61901184b639aafb98,
title = "Standard versus high loading doses of clopidogrel in Asian ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention: Insights from the Korea acute myocardial infarction registry",
abstract = "Background: The optimal loading dose of clopidogrel in Asian patients with ST-segment elevation myocardial infarction (STEMI) has not been fully investigated. We compared bleeding, vascular complications, and midterm outcomes of a 300-mg versus a 600-mg loading dose of clopidogrel in a large series of Korean patients with STEMI undergoing primary percutaneous coronary intervention (PCI). Methods: A total of 2,664 STEMI patients (age 61.96 ± 11.91 years, men 70.4{\%}) who underwent primary PCI were enrolled in this study. The patients were divided into a standard loading dose group (300 mg; n = 1,447 patients) and a high loading dose group (600 mg; n = 1,217 patients). Bleeding and vascular complications, and in-hospital and clinical outcomes up to 12 months were compared between the 2 groups. Results: In-hospital bleeding and vascular complications were similar between the 2 groups. There were no differences in bleeding and vascular complications and in 1- and 12-month clinical outcomes, including mortality, myocardial infarction, repeated PCI, and major adverse cardiac events, between the 2 groups. These findings were consistent even after the propensity score-matched analysis. Conclusions: The standard loading dose of clopidogrel may be as safe and similarly effective as the high loading dose in Asian STEMI patients undergoing primary PCI.",
author = "Choi, {Cheol Ung} and Seung-Woon Rha and Oh, {Dong Joo} and Poddar, {Kanhaiya L.} and Na, {Jin Oh} and Kim, {Jin Won} and Lim, {Hong Euy} and Kim, {Eung Ju} and Park, {Chang Gyu} and Seo, {Hong Seog} and Hong, {Taek Jong} and Park, {Jong Seon} and Kim, {Young Jo} and Hur, {Seung Ho} and Seong, {In Whan} and Chae, {Jei Keon} and Cho, {Myeong Chan} and Bae, {Jang Ho} and Choi, {Dong Hoon} and Jang, {Yang Soo} and Chae, {In Ho} and Kim, {Hyo Soo} and Kim, {Chong Jin} and Yoon, {Jung Han} and Ahn, {Tae Hoon} and Tahk, {Seung Jea} and Chung, {Wook Sung} and Seung, {Ki Bae} and Chae, {Shung Chall} and Park, {Seung Jung} and Ahn, {Young Keun} and Jeong, {Myung Ho}",
year = "2011",
month = "2",
day = "1",
doi = "10.1016/j.ahj.2010.10.031",
language = "English",
volume = "161",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby Inc.",
number = "2",

}

TY - JOUR

T1 - Standard versus high loading doses of clopidogrel in Asian ST-segment elevation myocardial infarction patients undergoing percutaneous coronary intervention

T2 - Insights from the Korea acute myocardial infarction registry

AU - Choi, Cheol Ung

AU - Rha, Seung-Woon

AU - Oh, Dong Joo

AU - Poddar, Kanhaiya L.

AU - Na, Jin Oh

AU - Kim, Jin Won

AU - Lim, Hong Euy

AU - Kim, Eung Ju

AU - Park, Chang Gyu

AU - Seo, Hong Seog

AU - Hong, Taek Jong

AU - Park, Jong Seon

AU - Kim, Young Jo

AU - Hur, Seung Ho

AU - Seong, In Whan

AU - Chae, Jei Keon

AU - Cho, Myeong Chan

AU - Bae, Jang Ho

AU - Choi, Dong Hoon

AU - Jang, Yang Soo

AU - Chae, In Ho

AU - Kim, Hyo Soo

AU - Kim, Chong Jin

AU - Yoon, Jung Han

AU - Ahn, Tae Hoon

AU - Tahk, Seung Jea

AU - Chung, Wook Sung

AU - Seung, Ki Bae

AU - Chae, Shung Chall

AU - Park, Seung Jung

AU - Ahn, Young Keun

AU - Jeong, Myung Ho

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Background: The optimal loading dose of clopidogrel in Asian patients with ST-segment elevation myocardial infarction (STEMI) has not been fully investigated. We compared bleeding, vascular complications, and midterm outcomes of a 300-mg versus a 600-mg loading dose of clopidogrel in a large series of Korean patients with STEMI undergoing primary percutaneous coronary intervention (PCI). Methods: A total of 2,664 STEMI patients (age 61.96 ± 11.91 years, men 70.4%) who underwent primary PCI were enrolled in this study. The patients were divided into a standard loading dose group (300 mg; n = 1,447 patients) and a high loading dose group (600 mg; n = 1,217 patients). Bleeding and vascular complications, and in-hospital and clinical outcomes up to 12 months were compared between the 2 groups. Results: In-hospital bleeding and vascular complications were similar between the 2 groups. There were no differences in bleeding and vascular complications and in 1- and 12-month clinical outcomes, including mortality, myocardial infarction, repeated PCI, and major adverse cardiac events, between the 2 groups. These findings were consistent even after the propensity score-matched analysis. Conclusions: The standard loading dose of clopidogrel may be as safe and similarly effective as the high loading dose in Asian STEMI patients undergoing primary PCI.

AB - Background: The optimal loading dose of clopidogrel in Asian patients with ST-segment elevation myocardial infarction (STEMI) has not been fully investigated. We compared bleeding, vascular complications, and midterm outcomes of a 300-mg versus a 600-mg loading dose of clopidogrel in a large series of Korean patients with STEMI undergoing primary percutaneous coronary intervention (PCI). Methods: A total of 2,664 STEMI patients (age 61.96 ± 11.91 years, men 70.4%) who underwent primary PCI were enrolled in this study. The patients were divided into a standard loading dose group (300 mg; n = 1,447 patients) and a high loading dose group (600 mg; n = 1,217 patients). Bleeding and vascular complications, and in-hospital and clinical outcomes up to 12 months were compared between the 2 groups. Results: In-hospital bleeding and vascular complications were similar between the 2 groups. There were no differences in bleeding and vascular complications and in 1- and 12-month clinical outcomes, including mortality, myocardial infarction, repeated PCI, and major adverse cardiac events, between the 2 groups. These findings were consistent even after the propensity score-matched analysis. Conclusions: The standard loading dose of clopidogrel may be as safe and similarly effective as the high loading dose in Asian STEMI patients undergoing primary PCI.

UR - http://www.scopus.com/inward/record.url?scp=79851509176&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79851509176&partnerID=8YFLogxK

U2 - 10.1016/j.ahj.2010.10.031

DO - 10.1016/j.ahj.2010.10.031

M3 - Article

C2 - 21315222

AN - SCOPUS:79851509176

VL - 161

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

IS - 2

ER -