Standing-wave design of a simulated moving bed under a pressure limit for enantioseparation of phenylpropanolamine

Ki Bong Lee, Chim Y. Chin, Yi Xie, Geoffrey B. Cox, Nien Hwa Linda Wang

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

An improved standing-wave design method is developed for nonlinear simulated moving bed (SMB) systems with significant mass-transfer effects and an operating pressure limit. The design method was verified with rate model simulations and then tested for enantioseparation of phenylpropanolamine. High purity (>99%) and high yield (>99%) were achieved experimentally using a SMB with a pressure limit of 350 psi. The verified design method was used to find the optimal column length that gives the maximum throughput per bed volume. For a given particle size and a pressure limit, the optimal column length falls on the boundary between the masstransfer-limiting region and the pressure-limiting region. If a characteristic dispersion velocity is more than 0.2% of an interstitial velocity, mass-transfer effects must be considered in the design in order to guarantee 99% purity and yield.

Original languageEnglish
Pages (from-to)3249-3267
Number of pages19
JournalIndustrial and Engineering Chemistry Research
Volume44
Issue number9
DOIs
Publication statusPublished - 2005 Apr 27
Externally publishedYes

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Phenylpropanolamine
standing wave
design method
mass transfer
Mass transfer
Particle size
particle size
Throughput
simulation
effect

ASJC Scopus subject areas

  • Polymers and Plastics
  • Environmental Science(all)
  • Chemical Engineering (miscellaneous)

Cite this

Standing-wave design of a simulated moving bed under a pressure limit for enantioseparation of phenylpropanolamine. / Lee, Ki Bong; Chin, Chim Y.; Xie, Yi; Cox, Geoffrey B.; Wang, Nien Hwa Linda.

In: Industrial and Engineering Chemistry Research, Vol. 44, No. 9, 27.04.2005, p. 3249-3267.

Research output: Contribution to journalArticle

Lee, Ki Bong ; Chin, Chim Y. ; Xie, Yi ; Cox, Geoffrey B. ; Wang, Nien Hwa Linda. / Standing-wave design of a simulated moving bed under a pressure limit for enantioseparation of phenylpropanolamine. In: Industrial and Engineering Chemistry Research. 2005 ; Vol. 44, No. 9. pp. 3249-3267.
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