Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells

YongKeun Park, Monica Diez-Silva, Dan Fu, Gabriel Popescu, Wonshik Choi, Ishan Barman, Subra Suresh, Michael S. Feld

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Abstract

We present the light scattering of individual Plasmodium falciparum-parasitized human red blood cells (Pf-RBCs), and demonstrate progressive alterations to the scattering signal arising from the development of malaria-inducing parasites. By selectively imaging the electric fields using quantitative phase microscopy and a Fourier transform light scattering technique, we calculate the light scattering maps of individual Pf-RBCs. We show that the onset and progression of pathological states of the Pf-RBCs can be clearly identified by the static scattering maps. Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering.

Original languageEnglish
Article number020506
JournalJournal of Biomedical Optics
Volume15
Issue number2
DOIs
Publication statusPublished - 2010 Dec 1

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Keywords

  • Electric field
  • Light scattering
  • Malaria
  • Plasmodium falciparum
  • Red blood cell

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

Cite this

Park, Y., Diez-Silva, M., Fu, D., Popescu, G., Choi, W., Barman, I., Suresh, S., & Feld, M. S. (2010). Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells. Journal of Biomedical Optics, 15(2), [020506]. https://doi.org/10.1117/1.3369966