Statins improve survival in patients with cardioembolic stroke

Jeong Yoon Choi, Woo Keun Seo, Sung Hoon Kang, Jin Man Jung, Kyung Hee Cho, Sungwook Yu, Kyungmi Oh

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background and Purpose: The objective of this study was to investigate the potential benefits of statin therapy on mortality and stroke recurrence after cardioembolic stroke. METHODS-: In this retrospective observational study, we analyzed data from 535 patients with first-ever cardioembolic stroke. Patients were classified into nonstatin, low-potency statin, and high-potency statin groups. The primary outcomes were time to mortality and time to recurrent stroke. RESULTS-: The mean duration of follow-up was 22.2 months. The cumulative mortality rate was 7% at the end of the first year and 10% at the end of the third year. Statin therapy was independently associated with reduced mortality (hazard ratio, 0.237; 95% confidence interval, 0.080-0.703 for nonstatin versus low-potency statin; hazard ratio, 0.158; 95% confidence interval, 0.037-0.686 for nonstatin versus high-potency statin). Statin treatment did not affect the incidence of recurrent stroke in patients with cardioembolic stroke. CONCLUSIONS-: Statin therapy could be associated with reduced mortality in patients with cardioembolic stroke.

Original languageEnglish
Pages (from-to)1849-1852
Number of pages4
JournalStroke
Volume45
Issue number6
DOIs
Publication statusPublished - 2014 Jun

Keywords

  • embolism
  • mortality
  • outcome
  • recurrence
  • statin
  • stroke

ASJC Scopus subject areas

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialised Nursing

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  • Cite this

    Choi, J. Y., Seo, W. K., Kang, S. H., Jung, J. M., Cho, K. H., Yu, S., & Oh, K. (2014). Statins improve survival in patients with cardioembolic stroke. Stroke, 45(6), 1849-1852. https://doi.org/10.1161/STROKEAHA.114.005518