A stereoselective synthesis of entecavir, an anti-hepatitis B (HBV) drug, was accomplished by a regioselective isopropylidene cleavage, stereoselective Sharpless epoxidation, and TiIII-mediated regio- and stereoselective epoxide cleavage as key steps.
|Journal||Asian Journal of Organic Chemistry|
|Publication status||Accepted/In press - 2017|
- Carbocyclic nucleoside
- Hepatitis B
- Stereoselective synthesis
ASJC Scopus subject areas
- Organic Chemistry