Stereoselective Synthesis of Anti-HepatitisB Drug, Entecavir, through Regio- and Stereoselective Epoxide Cleavage

Young Eum Hyun, Hong Rae Kim, Yongseok Choi, Lak Shin Jeong

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

A stereoselective synthesis of entecavir, an anti-hepatitis B (HBV) drug, was accomplished by a regioselective isopropylidene cleavage, stereoselective Sharpless epoxidation, and TiIII-mediated regio- and stereoselective epoxide cleavage as key steps.

Original languageEnglish
JournalAsian Journal of Organic Chemistry
DOIs
Publication statusAccepted/In press - 2017

Keywords

  • Carbocyclic nucleoside
  • Entecavir
  • Hepatitis B
  • Stereoselective synthesis
  • Titanium

ASJC Scopus subject areas

  • Organic Chemistry

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