Stereoselectivity in the condensation reactions between malate enolate and imines to 2-pyrrolidinone derivatives

Deok-Chan Ha, Kyeong Soon Yun, Hye Sang Park, Won Keun Choung, Young Eun Kwon

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Enolate dianion of diethyl (S)-malate was stereoselectively condensed with nonenoiizable N-arylimines to give 2-pyrrolidinone derivatives. The presence of HMPA changes the diastereoselectivity of this cyclization reaction.

Original languageEnglish
Pages (from-to)8445-8448
Number of pages4
JournalTetrahedron Letters
Volume36
Issue number46
DOIs
Publication statusPublished - 1995 Nov 13

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Hempa
Stereoselectivity
Imines
Condensation reactions
Cyclization
Derivatives
malic acid
2-pyrrolidone
diethyl malate

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Biochemistry

Cite this

Stereoselectivity in the condensation reactions between malate enolate and imines to 2-pyrrolidinone derivatives. / Ha, Deok-Chan; Yun, Kyeong Soon; Park, Hye Sang; Choung, Won Keun; Kwon, Young Eun.

In: Tetrahedron Letters, Vol. 36, No. 46, 13.11.1995, p. 8445-8448.

Research output: Contribution to journalArticle

Ha, Deok-Chan ; Yun, Kyeong Soon ; Park, Hye Sang ; Choung, Won Keun ; Kwon, Young Eun. / Stereoselectivity in the condensation reactions between malate enolate and imines to 2-pyrrolidinone derivatives. In: Tetrahedron Letters. 1995 ; Vol. 36, No. 46. pp. 8445-8448.
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