Stereospecific ring expansion of β-lactams to γ-lactams with trimethylsilyldiazomethane

Deok Chan Ha, Seogshin Kang, Coo Min Chung, Hyun Kyung Lim

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Ring opening of N-carboxylated β-lactams with trimethylsilyldiazomethane anion followed by photolytic Wolff rearrangement provided γ-lactams in a stereospecific manner.

Original languageEnglish
Pages (from-to)7541-7544
Number of pages4
JournalTetrahedron Letters
Volume39
Issue number41
DOIs
Publication statusPublished - 1998 Oct 8

Keywords

  • Azetidinones
  • Pyrrolidinones
  • Rearrangements
  • Ring-transformations

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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