Stereotactic Body Radiation Therapy Boost in Locally Advanced Pancreatic Cancer

Young Seok Seo, Mi Sook Kim, Sung Yul Yoo, Chul Koo Cho, Kwang Mo Yang, Hyung Jun Yoo, Chul Won Choi, Dong Han Lee, Jin Kim, Min Suk Kim, Hye Jin Kang, Young Han Kim

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Purpose: To investigate the clinical application of a stereotactic body radiation therapy (SBRT) boost in locally advanced pancreatic cancer patients with a focus on local efficacy and toxicity. Methods and Materials: We retrospectively reviewed 30 patients with locally advanced and nonmetastatic pancreatic cancer who had been treated between 2004 and 2006. Follow-up duration ranged from 4 to 41 months (median, 14.5 months). A total dose of 40 Gy was delivered in 20 fractions using a conventional three-field technique, and then a single fraction of 14, 15, 16, or 17 Gy SBRT was administered as a boost without a break. Twenty-one patients received chemotherapy. Overall and local progression-free survival were calculated and prognostic factors were evaluated. Results: One-year overall survival and local progression-free survival rates were 60.0% and 70.2%, respectively. One patient (3%) developed Grade 4 toxicity. Carbohydrate antigen 19-9 response was found to be an independent prognostic factor for survival. Conclusions: Our findings indicate that a SBRT boost provides a safe means of increasing radiation dose. Based on the results of this study, we recommend that a well controlled Phase II study be conducted on locally advanced pancreatic cancer.

Original languageEnglish
Pages (from-to)1456-1461
Number of pages6
JournalInternational Journal of Radiation Oncology Biology Physics
Volume75
Issue number5
DOIs
Publication statusPublished - 2009 Dec 1

Keywords

  • CyberKnife
  • Pancreatic cancer
  • Radiation therapy
  • Stereotactic

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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  • Cite this

    Seo, Y. S., Kim, M. S., Yoo, S. Y., Cho, C. K., Yang, K. M., Yoo, H. J., Choi, C. W., Lee, D. H., Kim, J., Kim, M. S., Kang, H. J., & Kim, Y. H. (2009). Stereotactic Body Radiation Therapy Boost in Locally Advanced Pancreatic Cancer. International Journal of Radiation Oncology Biology Physics, 75(5), 1456-1461. https://doi.org/10.1016/j.ijrobp.2009.01.042