Stereotactic body radiation therapy using three fractions for isolated lung recurrence from colorectal cancer

Mi Sook Kim, Sung Yul Yoo, Chul Koo Cho, Hyung Jun Yoo, Chul Won Choi, Young Seok Seo, Jin Kyu Kang, Dong Han Lee, Dae Yong Hwang, Sun Mi Moon, Min Suk Kim, Hye Jin Kang, Young Han Kim

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Objective: To determine the feasibility of stereotactic body radiotherapy (SBRT) using 3 fractions for isolated colorectal lung metastases. Methods: From June 2003 to December 2006, 13 cases of isolated pulmonary metastasis from colorectal cancer were treated by SBRT due to an inoperable state (7 patients), or the patient's refusal to undergo surgical excision (6 patients). All patients underwent chemotherapy for salvage treatment. SBRT doses ranged from 39 to 51 Gy in 3 fractions. Nine patients had a solitary lesion, 3 patients had 2 lesions, and 1 patient had 3 lesions. Median tumor volume for the 18 lesions was 5.9 ml (range 1.6-45 ml). Results: Follow-up duration was 15-57 months. Three-year overall survival, local control and progression-free survival rates were 64.7, 52.7 and 11.5%, respectively.Univariate analysis showed that total internal target volume was a significant prognostic factor for local control. During the follow-up, 11 of the 13 patients experienced local recurrence, distant metastasis or both. The most frequent site of failure was in a nontargeted lung region. No severe complication was attributed to SBRT. Conclusion: Our study suggests the potential feasibility of SBRT for selected patients with 1-3 small metastatic nodules. A further larger-scale study is required to define the indications for SBRT in cases with isolated pulmonary metastasis from colorectal cancer.

Original languageEnglish
Pages (from-to)212-219
Number of pages8
JournalOncology
Volume76
Issue number3
DOIs
Publication statusPublished - 2009 Mar 1
Externally publishedYes

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Colorectal Neoplasms
Radiotherapy
Radiosurgery
Recurrence
Lung
Neoplasm Metastasis
Salvage Therapy
Tumor Burden
Disease-Free Survival
Survival Rate
Drug Therapy
Survival

Keywords

  • Colorectal cancer
  • Lung recurrence
  • Stereotactic body radiation therapy

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Stereotactic body radiation therapy using three fractions for isolated lung recurrence from colorectal cancer. / Kim, Mi Sook; Yoo, Sung Yul; Cho, Chul Koo; Yoo, Hyung Jun; Choi, Chul Won; Seo, Young Seok; Kang, Jin Kyu; Lee, Dong Han; Hwang, Dae Yong; Moon, Sun Mi; Kim, Min Suk; Kang, Hye Jin; Kim, Young Han.

In: Oncology, Vol. 76, No. 3, 01.03.2009, p. 212-219.

Research output: Contribution to journalArticle

Kim, MS, Yoo, SY, Cho, CK, Yoo, HJ, Choi, CW, Seo, YS, Kang, JK, Lee, DH, Hwang, DY, Moon, SM, Kim, MS, Kang, HJ & Kim, YH 2009, 'Stereotactic body radiation therapy using three fractions for isolated lung recurrence from colorectal cancer', Oncology, vol. 76, no. 3, pp. 212-219. https://doi.org/10.1159/000201932
Kim, Mi Sook ; Yoo, Sung Yul ; Cho, Chul Koo ; Yoo, Hyung Jun ; Choi, Chul Won ; Seo, Young Seok ; Kang, Jin Kyu ; Lee, Dong Han ; Hwang, Dae Yong ; Moon, Sun Mi ; Kim, Min Suk ; Kang, Hye Jin ; Kim, Young Han. / Stereotactic body radiation therapy using three fractions for isolated lung recurrence from colorectal cancer. In: Oncology. 2009 ; Vol. 76, No. 3. pp. 212-219.
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