Steroid biosynthesis within the frog brain: A model of neuroendocrine regulation

Jean Luc Do Rego, Jae Young Seong, Delphine Burel, Van Luu-The, Dan Larhammar, Kazuyoshi Tsutsui, Georges Pelletier, Marie Christine Tonon, Hubert Vaudry

Research output: Chapter in Book/Report/Conference proceedingConference contribution

17 Citations (Scopus)

Abstract

There is now clear evidence that the brain, similar to the adrenal gland, gonads, and placenta, is a steroidogenic organ. Notably in the frog brain, the presence of various steroidogenic enzymes has been detected by immunohistochemistry in specific populations of neurons and/or glial cells. These steroidogenic enzymes are biologically active, as shown by the ability of brain tissue explants to convert [3H]pregnenolone into various radiolabeled steroids. The frog brain has also been extensively used as a model to study the mechanism of regulation of neurosteroidogenesis by neurotransmitters and neuropeptides. It has been demonstrated that the biosynthesis of neurosteroids is inhibited by γ-aminobutyric acid (GABA), acting through GABAA receptors, and neuropeptide Y, acting through Y1 receptors, and is stimulated by the octadecaneuropeptide (ODN), acting through central-type benzodiazepine receptors, triakontatetraneuropeptide (TTN), acting through peripheral-type benzodiazepine receptors, and vasotocin, acting through V1a-like receptors. These data indicate that some of the neurophysiological effects of neurotransmitters and neuropeptides may be mediated through modulation of neurosteroid biosynthesis.

Original languageEnglish
Title of host publicationAnnals of the New York Academy of Sciences
Pages83-92
Number of pages10
Volume1163
DOIs
Publication statusPublished - 2009 Apr 1

Publication series

NameAnnals of the New York Academy of Sciences
Volume1163
ISSN (Print)00778923
ISSN (Electronic)17496632

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Biosynthesis
Anura
Neurotransmitter Agents
Brain
GABA-A Receptors
Steroids
diazepam binding inhibitor (33-50)
Neuropeptides
Vasotocin
Aminobutyrates
Pregnenolone
Neuropeptide Y
Gonads
Enzymes
Adrenal Glands
Neuroglia
gamma-Aminobutyric Acid
Placenta
Neurons
Immunohistochemistry

Keywords

  • Amphibians
  • Brain
  • Neuropeptides
  • Neurosteroids
  • Neurotransmitters

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Do Rego, J. L., Seong, J. Y., Burel, D., Luu-The, V., Larhammar, D., Tsutsui, K., ... Vaudry, H. (2009). Steroid biosynthesis within the frog brain: A model of neuroendocrine regulation. In Annals of the New York Academy of Sciences (Vol. 1163, pp. 83-92). (Annals of the New York Academy of Sciences; Vol. 1163). https://doi.org/10.1111/j.1749-6632.2008.03664.x

Steroid biosynthesis within the frog brain : A model of neuroendocrine regulation. / Do Rego, Jean Luc; Seong, Jae Young; Burel, Delphine; Luu-The, Van; Larhammar, Dan; Tsutsui, Kazuyoshi; Pelletier, Georges; Tonon, Marie Christine; Vaudry, Hubert.

Annals of the New York Academy of Sciences. Vol. 1163 2009. p. 83-92 (Annals of the New York Academy of Sciences; Vol. 1163).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Do Rego, JL, Seong, JY, Burel, D, Luu-The, V, Larhammar, D, Tsutsui, K, Pelletier, G, Tonon, MC & Vaudry, H 2009, Steroid biosynthesis within the frog brain: A model of neuroendocrine regulation. in Annals of the New York Academy of Sciences. vol. 1163, Annals of the New York Academy of Sciences, vol. 1163, pp. 83-92. https://doi.org/10.1111/j.1749-6632.2008.03664.x
Do Rego JL, Seong JY, Burel D, Luu-The V, Larhammar D, Tsutsui K et al. Steroid biosynthesis within the frog brain: A model of neuroendocrine regulation. In Annals of the New York Academy of Sciences. Vol. 1163. 2009. p. 83-92. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2008.03664.x
Do Rego, Jean Luc ; Seong, Jae Young ; Burel, Delphine ; Luu-The, Van ; Larhammar, Dan ; Tsutsui, Kazuyoshi ; Pelletier, Georges ; Tonon, Marie Christine ; Vaudry, Hubert. / Steroid biosynthesis within the frog brain : A model of neuroendocrine regulation. Annals of the New York Academy of Sciences. Vol. 1163 2009. pp. 83-92 (Annals of the New York Academy of Sciences).
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