Stimulation of 2,3-butanediol production by upregulation of alsR gene transcription level with acetate addition in Enterobacter aerogenes ATCC 29007

Sang Jun Lee, Laxmi Prasad Thapa, Ju Hun Lee, Han Suk Choi, Sung Bong Kim, Chulhwan Park, Seung Wook Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)


2,3-Butanediol is an attractive product for biorefinery due to its various applications and industrial potential. Enterobacter aerogenes is also considered as a major 2,3-butanediol producer. This study is intended to enhance the production of 2,3-butanediol with addition of acetate into the culture media using E. aerogenes ATCC 29007 and to determine the mechanism of improved 2,3-butanediol production. 2,3-Butanediol production was increased by 34.2% with the addition of acetate in batch culture compared to that without acetate in 130 g/L of glucose. This increase was caused by buffering effects and upregulation of the transcription levels of genes involved in 2,3-butanediol production through acetate addition.

Original languageEnglish
Pages (from-to)1904-1910
Number of pages7
JournalProcess Biochemistry
Issue number12
Publication statusPublished - 2016 Dec 1



  • 2,3-Butanediol
  • Acetate
  • Enterobacter aerogenes
  • Fermentation
  • Transcriptional regulation

ASJC Scopus subject areas

  • Bioengineering
  • Biochemistry
  • Applied Microbiology and Biotechnology

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