Stimulation of cephalosporin C production in Acremonium chrysogenum M35 by glycerol

Hyun Yong Shin, Jin Young Lee, You Ree Jung, Seung Wook Kim

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

In this study, the effects of glycerol on cephalosporin C production by Acremonium chrysogenum M35 were evaluated. The addition of glycerol increased cephalosporin production by up to 12-fold. Glycerol caused the upregulation of the transcription of the isopenicillin synthase (pcbC) and transporter (cefT) genes in early exponential phase, and affected the cell morphology since hyphal fragments differentiated into arthrospores. These results indicate that glycerol effectively enhances cephalosporin C production via stimulation of cell differentiation.

Original languageEnglish
Pages (from-to)4549-4553
Number of pages5
JournalBioresource technology
Volume101
Issue number12
DOIs
Publication statusPublished - 2010 Jun

Keywords

  • Acremonium chrysogenum
  • Glycerol
  • Isopenicillin N synthase
  • Morphological characteristics
  • Transporter

ASJC Scopus subject areas

  • Bioengineering
  • Environmental Engineering
  • Renewable Energy, Sustainability and the Environment
  • Waste Management and Disposal

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