@article{04adb829363b4006b2a5df0924448178,
title = "Stress is associated with poor outcome of acute treatment for chronic migraine: A multicenter study",
abstract = "Background. Chronic migraine (CM) is associated with severe psychological symptoms and disabilities. Information on the relationship between stress and the outcomes of acute CM treatment is limited. Methods. We evaluated the clinical presentation and stress levels of patients with CM who visited the neurology departments of 14 hospitals between September and December 2015. The patients were divided into stress and reference groups on the basis of the Korean version of the Brief Encounter Psychosocial Instrument (BEPSI-K). Quality of life was evaluated using EuroQol Five Dimension Questionnaire Three-Level. The Migraine Assessment of Current Therapy questionnaire was used to assess the outcomes of acute treatment. Results. This study included 186 CM patients. On the basis of the BEPSI-K score, 79 and 107 patients were assigned to the stress and reference groups, respectively. The stress group had more patients with poor outcomes of acute treatment than the reference group (67.1% vs 40.2%, P < 0.001). In a multivariate analysis, female gender (odds ratio [OR] 5 3.266, 95% confidence interval [CI] 5 1.172-9.103, P 5 0.024), the number of headache-free days per month (OR 5 0.932, 95% CI 5 0.883-0.985, P 5 0.012), and BEPSI-K score (OR 5 1.667, 95% CI 5 1.051-2.643, P 5 0.030) predicted poor outcomes of acute treatment. Conclusions. High levels of stress were reported by 42.5% of patients with CM. The association between stress and the outcomes of acute treatment suggests that stress is an important clinical variable for improving the management of CM.",
keywords = "Chronic Migraine, Headache Disorders, Migraine, Psychological Stress, Quality of Life, Treatment Outcome",
author = "Cha, {Myoung Jin} and Kim, {Byung Kun} and Moon, {Heui Soo} and Ahn, {Jin Young} and Kyungmi Oh and Kim, {Jee Young} and Kim, {Byung Su} and Sohn, {Jong Hee} and Chung, {Jae Myun} and Song, {Tae Jin} and Jiyoung Kim and Seo, {Jong Geun} and Chu, {Min Kyung} and Cho, {Soo Jin}",
note = "Funding Information: Conflicts of interest: Dr. Cha reports no conflict of interest. Dr. Kim was involved as a site investigator for a multicenter trial sponsored by Hanmi pharm. Lilly worked an advisory member for Allergan, Abott, TEVA, and Yuyu Pharm; and received lecture honoraria from Allergan and Sandoz. Dr. Moon reports no conflict of interest. Dr. Ahn reports no conflict of interest. Dr. Oh was involved in a Lilly multicenter trial. Dr. Kim reports no conflict of interest. Dr. Kim reports no conflict of interest. Dr. Sohn reports no conflict of interest. Dr. Chung reports no conflict of interest. Dr. Song reports no conflict of interest. Dr. Kim reports no conflict of interest. Dr. Seo reports no conflict of interest. Dr. Chu was involved as a site investigator for a multicenter trial sponsored by Eli Lilly, worked an advisory member for Teva, and received lecture honoraria from Allergan Korea and Yuyu Pharmaceutical Company. Dr. Cho was involved as a site investigator of a multicenter trial sponsored by Otsuka Korea, Eli Lilly and Company, Korea BMS, and Eisai Korea; and received research support from Hallym University Research Fund 2016 and lecture honoraria from Yuyu Pharmaceutical Company. Funding Information: Funding sources: This study was supported by a grant from the Korean Headache Society. Publisher Copyright: {\textcopyright} 2017 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com",
year = "2018",
month = sep,
day = "1",
doi = "10.1093/pm/pnx269",
language = "English",
volume = "19",
pages = "1832--1838",
journal = "Pain Medicine",
issn = "1526-2375",
publisher = "Wiley-Blackwell",
number = "9",
}