Abstract
Excessive stress gives rise to disturbances in various systems in humans and activates defense mechanisms to maintain homeostasis in the body. Sleep is an essential biological process of which the underlying regulating mechanism involves numerous anatomical structures and biochemical substances that can be compromised by stress and the immune system. Immune sub-stances such as interleukin-1β and tumor necrosis factor are related to the homeostatic process of sleep. Interleukin-1β interacts by being involved in an immune regulating feedback chain that activates the hypothalamo-pituitary-adrenal axis which, in turn, is related to the circadian process. Moreover, stress-induced insomnia activates the hypothalamo-pituitary-adrenal axis further to bring about a vicious cycle of stress and insomnia. The pathophysiological theory responsible for chronic insomnia is that of stressdiathesis, which is a series of processes consisting of predisposition, precipitating, and perpetuating factors. In clinical practice, as the process in which stressinduced insomnia passes into a chronic course is directly related to treatment, the understanding of perpetuating factors is indispensable. Sleep disturbance is a very common complaint among patients with posttraumatic stress disorder. Increased noradrenergic activity and REM sleep dysregulation seem to have a role in mediating sleep disturbances of this disorder. Sleep disturbance must always be taken into account as an important clinical variable whenever evaluating or managing stress.
| Original language | English |
|---|---|
| Pages (from-to) | 707-716 |
| Number of pages | 10 |
| Journal | Journal of the Korean Medical Association |
| Volume | 53 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2010 Aug 1 |
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Keywords
- Cognitive behavioral treatment
- Insomnia
- Posttraumatic stress disorder
- Sleep regulation
- Stress
ASJC Scopus subject areas
- Medicine(all)
Cite this
Stress, sleep physiology, and related insomnia disorders. / Kim, Leen.
In: Journal of the Korean Medical Association, Vol. 53, No. 8, 01.08.2010, p. 707-716.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Stress, sleep physiology, and related insomnia disorders
AU - Kim, Leen
PY - 2010/8/1
Y1 - 2010/8/1
N2 - Excessive stress gives rise to disturbances in various systems in humans and activates defense mechanisms to maintain homeostasis in the body. Sleep is an essential biological process of which the underlying regulating mechanism involves numerous anatomical structures and biochemical substances that can be compromised by stress and the immune system. Immune sub-stances such as interleukin-1β and tumor necrosis factor are related to the homeostatic process of sleep. Interleukin-1β interacts by being involved in an immune regulating feedback chain that activates the hypothalamo-pituitary-adrenal axis which, in turn, is related to the circadian process. Moreover, stress-induced insomnia activates the hypothalamo-pituitary-adrenal axis further to bring about a vicious cycle of stress and insomnia. The pathophysiological theory responsible for chronic insomnia is that of stressdiathesis, which is a series of processes consisting of predisposition, precipitating, and perpetuating factors. In clinical practice, as the process in which stressinduced insomnia passes into a chronic course is directly related to treatment, the understanding of perpetuating factors is indispensable. Sleep disturbance is a very common complaint among patients with posttraumatic stress disorder. Increased noradrenergic activity and REM sleep dysregulation seem to have a role in mediating sleep disturbances of this disorder. Sleep disturbance must always be taken into account as an important clinical variable whenever evaluating or managing stress.
AB - Excessive stress gives rise to disturbances in various systems in humans and activates defense mechanisms to maintain homeostasis in the body. Sleep is an essential biological process of which the underlying regulating mechanism involves numerous anatomical structures and biochemical substances that can be compromised by stress and the immune system. Immune sub-stances such as interleukin-1β and tumor necrosis factor are related to the homeostatic process of sleep. Interleukin-1β interacts by being involved in an immune regulating feedback chain that activates the hypothalamo-pituitary-adrenal axis which, in turn, is related to the circadian process. Moreover, stress-induced insomnia activates the hypothalamo-pituitary-adrenal axis further to bring about a vicious cycle of stress and insomnia. The pathophysiological theory responsible for chronic insomnia is that of stressdiathesis, which is a series of processes consisting of predisposition, precipitating, and perpetuating factors. In clinical practice, as the process in which stressinduced insomnia passes into a chronic course is directly related to treatment, the understanding of perpetuating factors is indispensable. Sleep disturbance is a very common complaint among patients with posttraumatic stress disorder. Increased noradrenergic activity and REM sleep dysregulation seem to have a role in mediating sleep disturbances of this disorder. Sleep disturbance must always be taken into account as an important clinical variable whenever evaluating or managing stress.
KW - Cognitive behavioral treatment
KW - Insomnia
KW - Posttraumatic stress disorder
KW - Sleep regulation
KW - Stress
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UR - http://www.scopus.com/inward/citedby.url?scp=77956077668&partnerID=8YFLogxK
U2 - 10.5124/jkma.2010.53.8.707
DO - 10.5124/jkma.2010.53.8.707
M3 - Article
VL - 53
SP - 707
EP - 716
JO - Journal of the Korean Medical Association
JF - Journal of the Korean Medical Association
SN - 1975-8456
IS - 8
ER -