Stroke outcomes are worse with larger leukoaraiosis volumes

Wi Sun Ryu, Sung Ho Woo, Dawid Schellingerhout, Min Uk Jang, Kyoung Jong Park, Keun Sik Hong, Sang Wuk Jeong, Jeong Yong Na, Ki Hyun Cho, Joon Tae Kim, Beom Joon Kim, Moon Ku Han, Jun Lee, Jae Kwan Cha, Dae Hyun Kim, Soo Joo Lee, Youngchai Ko, Yong Jin Cho, Byung Chul Lee, Kyung Ho YuMi Sun Oh, Jong Moo Park, Kyusik Kang, Kyung Bok Lee, Tai Hwan Park, Juneyoung Lee, Heung Kook Choi, Kiwon Lee, Hee Joon Bae, Dong Eog Kim

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29 Citations (Scopus)

Abstract

Leukoaraiosis or white matter hyperintensities are frequently observed on magnetic resonance imaging of stroke patients. We investigated how white matter hyperintensity volumes affect stroke outcomes, generally and by subtype. In total, 5035 acute ischaemic stroke patients were enrolled. Strokes were classified as large artery atherosclerosis, small vessel occlusion, or cardioembolism. White matter hyperintensity volumes were stratified into quintiles. Mean age (± standard deviation) was 66.3 ± 12.8, 59.6% male. Median (interquartile range) modified Rankin Scale score was 2 (1-3) at discharge and 1 (0-3) at 3 months; 16.5% experienced early neurological deterioration, and 3.3% recurrent stroke. The Cochran-Mantel-Haenszel test with adjustment for age, stroke severity, sex, and thrombolysis status showed that the distributions of 3-month modified Rankin Scale scores differed across white matter hyperintensity quintiles (P < 0.001). Multiple ordinal logistic regression analysis showed that higher white matter hyperintensity quintiles were independently associated with worse 3-month modified Rankin Scale scores; adjusted odds ratios (95% confidence interval) for the second to fifth quintiles versus the first quintile were 1.29 (1.10-1.52), 1.40 (1.18-1.66), 1.69 (1.42-2.02) and 2.03 (1.69-2.43), respectively. For large artery atherosclerosis (39.0%), outcomes varied by white matter hyperintensity volume (P = 0.01, Cochran-Mantel-Haenszel test), and the upper three white matter hyperintensity quintiles (versus the first quintile) had worse 3-month modified Rankin Scale scores; adjusted odds ratios were 1.45 (1.10-1.90), 1.86 (1.41-2.47), and 1.89 (1.41-2.54), respectively. Patients with large artery atherosclerosis were vulnerable to early neurological deterioration (19.4%), and the top two white matter hyperintensity quintiles were more vulnerable still: 23.5% and 22.3%. Moreover, higher white matter hyperintensities were associated with poor modified Rankin Scale improvement: adjusted odds ratios for the upper two quintiles versus the first quintile were 0.66 (0.47-0.94) and 0.62 (0.43-0.89), respectively. For small vessel occlusion (17.8%), outcomes tended to vary by white matter hyperintensitiy volume (P = 0.10, Cochran-Mantel-Haenszel test), and the highest quintile was associated with worse 3-month modified Rankin Scale scores: adjusted odds ratio for the fifth quintile versus first quintile, 1.98 (1.23-3.18). In this subtype, worse white matter hyperintensities were associated with worse National Institute of Health Stroke Scale scores at presentation. For cardioembolism (20.6%), outcomes did not vary significantly by white matter hyperintensity volume (P = 0.19, Cochran-Mantel-Haenszel test); however, the adjusted odds ratio for the highest versus lowest quintiles was 1.62 (1.09-2.40). Regardless of stroke subtype, white matter hyperintensities were not associated with stroke recurrence within 3 months of follow-up. In conclusion, white matter hyperintensity volume independently correlates with stroke outcomes in acute ischaemic stroke. There are some suggestions that stroke outcomes may be affected by leukoaraiosis differentially depending on stroke subtypes, to be confirmed in future investigations.

Original languageEnglish
Pages (from-to)158-170
Number of pages13
JournalBrain : a journal of neurology
Volume140
Issue number1
DOIs
Publication statusPublished - 2017 Jan 1

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Keywords

  • ischaemic stroke
  • magnetic resonance image
  • outcome
  • white matter hyperintensities

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

Ryu, W. S., Woo, S. H., Schellingerhout, D., Jang, M. U., Park, K. J., Hong, K. S., Jeong, S. W., Na, J. Y., Cho, K. H., Kim, J. T., Kim, B. J., Han, M. K., Lee, J., Cha, J. K., Kim, D. H., Lee, S. J., Ko, Y., Cho, Y. J., Lee, B. C., ... Kim, D. E. (2017). Stroke outcomes are worse with larger leukoaraiosis volumes. Brain : a journal of neurology, 140(1), 158-170. https://doi.org/10.1093/brain/aww259