Strong and Biostable Hyaluronic Acid-Calcium Phosphate Nanocomposite Hydrogel via in Situ Precipitation Process

Seol Ha Jeong, Young-Hag Koh, Suk Wha Kim, Ji Ung Park, Hyoun Ee Kim, Juha Song

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Hyaluronic acid (HAc) hydrogel exhibits excellent biocompatibility, but it has limited biomedical application due to its poor biomechanical properties as well as too-fast enzymatic degradation. In this study, we have developed an in situ precipitation process for the fabrication of a HAc-calcium phosphate nanocomposite hydrogel, after the formation of the glycidyl methacrylate-conjugated HAc (GMHA) hydrogels via photo-cross-linking, to improve the mechanical and biological properties under physiological conditions. In particular, our process facilitates the rapid incorporation of calcium phosphate (CaP) nanoparticles of uniform size and with minimal agglomeration into a polymer matrix, homogeneously. Compared with pure HAc, the nanocomposite hydrogels exhibit improved mechanical behavior. Specifically, the shear modulus is improved by a factor of 4. The biostability of the nanocomposite hydrogel was also significantly improved compared with that of pure HAc hydrogels under both in vitro and in vivo conditions.

Original languageEnglish
Pages (from-to)841-851
Number of pages11
JournalBiomacromolecules
Volume17
Issue number3
DOIs
Publication statusPublished - 2016 Mar 14

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Hyaluronic acid
Hydrogel
Calcium phosphate
Hyaluronic Acid
Hydrogels
Nanocomposites
Polymer matrix
Biocompatibility
Agglomeration
Elastic moduli
monobasic calcium phosphate
Nanoparticles
Fabrication
Degradation

ASJC Scopus subject areas

  • Bioengineering
  • Materials Chemistry
  • Polymers and Plastics
  • Biomaterials

Cite this

Strong and Biostable Hyaluronic Acid-Calcium Phosphate Nanocomposite Hydrogel via in Situ Precipitation Process. / Jeong, Seol Ha; Koh, Young-Hag; Kim, Suk Wha; Park, Ji Ung; Kim, Hyoun Ee; Song, Juha.

In: Biomacromolecules, Vol. 17, No. 3, 14.03.2016, p. 841-851.

Research output: Contribution to journalArticle

Jeong, Seol Ha ; Koh, Young-Hag ; Kim, Suk Wha ; Park, Ji Ung ; Kim, Hyoun Ee ; Song, Juha. / Strong and Biostable Hyaluronic Acid-Calcium Phosphate Nanocomposite Hydrogel via in Situ Precipitation Process. In: Biomacromolecules. 2016 ; Vol. 17, No. 3. pp. 841-851.
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