Stronger associations of sagittal abdominal diameter with atherogenic lipoprotein subfractions than waist circumference in middle-aged US white and Japanese men

Katsumi Nakata, Jina Choo, Michael J S Hopson, Hirotsugu Ueshima, J. David Curb, Chol Shin, Rhobert W. Evans, Takashi Kadowaki, Teruo Otake, Aya Kadota, Syaka Kadowaki, Katsuyuki Miura, Aiman El-Saed, Daniel Edmundowicz, Kim Sutton-Tyrrell, Lewis H. Kuller, Akira Sekikawa

Research output: Contribution to journalArticle

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Abstract

Both sagittal abdominal diameter (SAD) and waist circumference (WC) highly correlate with visceral adipose tissue (VAT) being linked to an atherogenic lipoprotein profile. However, it is uncertain whether SAD is a better correlate of atherogenic lipoprotein subfractions than WC. We examined relative associations of SAD vs WC with lipoprotein subfractions for US white and Japanese men, concurrently examining the associations of VAT vs subcutaneous adipose tissue with lipoprotein subfractions. A population-based sample of 260 white and 282 Japanese men aged 40 to 49 years was examined for VAT and subcutaneous adipose tissue by computed tomography; SAD and WC by a portable sliding-beam caliper and a measuring tape, respectively; and lipoprotein subfractions by nuclear magnetic resonance spectroscopy. Both SAD and WC were significantly and positively associated with large very low-density lipoprotein and total and small low-density lipoprotein particle concentrations, and inversely associated with large high-density lipoprotein particle concentration for both white and Japanese men. In body mass index-adjusted regression models, the significant associations of SAD remained for both white and Japanese men, whereas those of WC became nonsignificant for white men. When SAD and WC were simultaneously included into the body mass index-adjusted models, the associations of SAD remained significant and statistically stronger than those of WC for both white and Japanese men. Furthermore, the pattern of the associations of SAD with those lipoprotein subfractions was comparable to that of the associations of VAT. Sagittal abdominal diameter was comparable to VAT and stronger than WC in the associations with atherogenic lipoprotein subfractions for middle-aged, nondiabetic, white and Japanese men.

Original languageEnglish
Pages (from-to)1742-1751
Number of pages10
JournalMetabolism: Clinical and Experimental
Volume59
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1

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Sagittal Abdominal Diameter
Waist Circumference
Lipoproteins
Intra-Abdominal Fat
Subcutaneous Fat
Body Mass Index
VLDL Lipoproteins
HDL Lipoproteins
LDL Lipoproteins

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Stronger associations of sagittal abdominal diameter with atherogenic lipoprotein subfractions than waist circumference in middle-aged US white and Japanese men. / Nakata, Katsumi; Choo, Jina; Hopson, Michael J S; Ueshima, Hirotsugu; Curb, J. David; Shin, Chol; Evans, Rhobert W.; Kadowaki, Takashi; Otake, Teruo; Kadota, Aya; Kadowaki, Syaka; Miura, Katsuyuki; El-Saed, Aiman; Edmundowicz, Daniel; Sutton-Tyrrell, Kim; Kuller, Lewis H.; Sekikawa, Akira.

In: Metabolism: Clinical and Experimental, Vol. 59, No. 12, 01.12.2010, p. 1742-1751.

Research output: Contribution to journalArticle

Nakata, K, Choo, J, Hopson, MJS, Ueshima, H, Curb, JD, Shin, C, Evans, RW, Kadowaki, T, Otake, T, Kadota, A, Kadowaki, S, Miura, K, El-Saed, A, Edmundowicz, D, Sutton-Tyrrell, K, Kuller, LH & Sekikawa, A 2010, 'Stronger associations of sagittal abdominal diameter with atherogenic lipoprotein subfractions than waist circumference in middle-aged US white and Japanese men', Metabolism: Clinical and Experimental, vol. 59, no. 12, pp. 1742-1751. https://doi.org/10.1016/j.metabol.2010.04.019
Nakata, Katsumi ; Choo, Jina ; Hopson, Michael J S ; Ueshima, Hirotsugu ; Curb, J. David ; Shin, Chol ; Evans, Rhobert W. ; Kadowaki, Takashi ; Otake, Teruo ; Kadota, Aya ; Kadowaki, Syaka ; Miura, Katsuyuki ; El-Saed, Aiman ; Edmundowicz, Daniel ; Sutton-Tyrrell, Kim ; Kuller, Lewis H. ; Sekikawa, Akira. / Stronger associations of sagittal abdominal diameter with atherogenic lipoprotein subfractions than waist circumference in middle-aged US white and Japanese men. In: Metabolism: Clinical and Experimental. 2010 ; Vol. 59, No. 12. pp. 1742-1751.
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AU - Nakata, Katsumi

AU - Choo, Jina

AU - Hopson, Michael J S

AU - Ueshima, Hirotsugu

AU - Curb, J. David

AU - Shin, Chol

AU - Evans, Rhobert W.

AU - Kadowaki, Takashi

AU - Otake, Teruo

AU - Kadota, Aya

AU - Kadowaki, Syaka

AU - Miura, Katsuyuki

AU - El-Saed, Aiman

AU - Edmundowicz, Daniel

AU - Sutton-Tyrrell, Kim

AU - Kuller, Lewis H.

AU - Sekikawa, Akira

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N2 - Both sagittal abdominal diameter (SAD) and waist circumference (WC) highly correlate with visceral adipose tissue (VAT) being linked to an atherogenic lipoprotein profile. However, it is uncertain whether SAD is a better correlate of atherogenic lipoprotein subfractions than WC. We examined relative associations of SAD vs WC with lipoprotein subfractions for US white and Japanese men, concurrently examining the associations of VAT vs subcutaneous adipose tissue with lipoprotein subfractions. A population-based sample of 260 white and 282 Japanese men aged 40 to 49 years was examined for VAT and subcutaneous adipose tissue by computed tomography; SAD and WC by a portable sliding-beam caliper and a measuring tape, respectively; and lipoprotein subfractions by nuclear magnetic resonance spectroscopy. Both SAD and WC were significantly and positively associated with large very low-density lipoprotein and total and small low-density lipoprotein particle concentrations, and inversely associated with large high-density lipoprotein particle concentration for both white and Japanese men. In body mass index-adjusted regression models, the significant associations of SAD remained for both white and Japanese men, whereas those of WC became nonsignificant for white men. When SAD and WC were simultaneously included into the body mass index-adjusted models, the associations of SAD remained significant and statistically stronger than those of WC for both white and Japanese men. Furthermore, the pattern of the associations of SAD with those lipoprotein subfractions was comparable to that of the associations of VAT. Sagittal abdominal diameter was comparable to VAT and stronger than WC in the associations with atherogenic lipoprotein subfractions for middle-aged, nondiabetic, white and Japanese men.

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