Structural analysis of F20L oligomeric and protofibrillar amyloid pair structures using molecular dynamics simulations

Hyun Joon Chang, Myeongsang Lee, Inchul Baek, Yoonjung Kim, Sung Soo Na

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Ap amyloid protein is representative agent, which is involved in neuro-degenerative diseases. Due to the undegrading characteristics under physiological conditions, understanding the structural characteristics of Aβ amyloid protein in detail is crucial. Many efforts have made on the lowering the structural stabilities of Aβ amyloid protein by decreasing the aromatic residues characteristic and hydrophobic effect. However, there lacks an understanding of Aβ amyloid pair structures in detail. In this work, we provide the structural characteristics of Aβ amyloid pair structures by selective leucine residue mutation on phenylalanine residue (F20L). We also considered the polymorphic feature of F20L Aβ amyloid pair based on NN, CC and NC compositions. Furthermore, we found the structural difference of oligomeric and fibrillar NC F20L Aβ amyloid pair structures in detail.

Original languageEnglish
Title of host publicationNanotechnology Materials and Devices Conference, NMDC 2016 - Conference Proceedings
PublisherInstitute of Electrical and Electronics Engineers Inc.
ISBN (Electronic)9781509043521
DOIs
Publication statusPublished - 2016 Dec 7
Event11th IEEE Nanotechnology Materials and Devices Conference, NMDC 2016 - Toulouse, France
Duration: 2016 Oct 92016 Oct 12

Other

Other11th IEEE Nanotechnology Materials and Devices Conference, NMDC 2016
CountryFrance
CityToulouse
Period16/10/916/10/12

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ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Electronic, Optical and Magnetic Materials

Cite this

Chang, H. J., Lee, M., Baek, I., Kim, Y., & Na, S. S. (2016). Structural analysis of F20L oligomeric and protofibrillar amyloid pair structures using molecular dynamics simulations. In Nanotechnology Materials and Devices Conference, NMDC 2016 - Conference Proceedings [7777124] Institute of Electrical and Electronics Engineers Inc.. https://doi.org/10.1109/NMDC.2016.7777124