Structural and biochemical analyses of the eukaryotic heat shock locus v (HslV) from Trypanosoma brucei

Kwang Hoon Sung, So Yeon Lee, Hyun Kyu Song

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: A eukaryotic HslV (TbHslV) protease and two potential HslU (TbHslU1 and TbHslU2) ATPases have been isolated from Trypanosoma brucei. Results: We determined the crystal structure of TbHslV at 2.4 Å resolution. Only TbHslU2 activated TbHslV protease activity. Conclusion: A key tyrosine residue in TbHslU2 required for activating TbHslV was identified. Significance: This study lays the groundwork for understanding the eukaryotic HslVU system.

Original languageEnglish
Pages (from-to)23234-23243
Number of pages10
JournalJournal of Biological Chemistry
Volume288
Issue number32
DOIs
Publication statusPublished - 2013 Aug 9

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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