Structural comparison of ligand-binding domains in estrogen-related receptors

Hye Yeon Kim, Ae Nim Pae, Yeon Joo Lee, Joonkyu Park, Dae Sung Kim, Kwang Yeon Hwang, Myeong Hee Yu, Eunice EunKyeong Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Estrogen-related receptors (ERRs), orphan nuclear receptors, share a significant amino acid sequence homology with estrogen receptors (ERs), yet their ligands do not respond in the same manner. In fact, some of the ligands that are known as agonists of ERs show antagonistic effect in ERRs. Accordingly, the current study investigated the structures of the ligand-binding domains using homology model building and docking studies. The results showed clear differences between the ligand-binding pockets of ERRs and ERs, thereby providing structural insights into the activities related to the ligands.

Original languageEnglish
Pages (from-to)107-112
Number of pages6
JournalKey Engineering Materials
Volume277-279
Issue numberI
Publication statusPublished - 2005 Dec 1
Externally publishedYes

Fingerprint

Estrogens
Ligands
Estrogen Receptors
Orphan Nuclear Receptors
Amino acids
Amino Acids

Keywords

  • 4-hydroxyltamoxifen (OHT)
  • Diethylstilbestrol (DES)
  • Estrogen receptor (ER)
  • Estrogen related receptor (ERR)
  • Homology modeling
  • Ligand-binding domain
  • Orphan nuclear receptor

ASJC Scopus subject areas

  • Ceramics and Composites
  • Chemical Engineering (miscellaneous)

Cite this

Kim, H. Y., Pae, A. N., Lee, Y. J., Park, J., Kim, D. S., Hwang, K. Y., ... Kim, E. E. (2005). Structural comparison of ligand-binding domains in estrogen-related receptors. Key Engineering Materials, 277-279(I), 107-112.

Structural comparison of ligand-binding domains in estrogen-related receptors. / Kim, Hye Yeon; Pae, Ae Nim; Lee, Yeon Joo; Park, Joonkyu; Kim, Dae Sung; Hwang, Kwang Yeon; Yu, Myeong Hee; Kim, Eunice EunKyeong.

In: Key Engineering Materials, Vol. 277-279, No. I, 01.12.2005, p. 107-112.

Research output: Contribution to journalArticle

Kim, HY, Pae, AN, Lee, YJ, Park, J, Kim, DS, Hwang, KY, Yu, MH & Kim, EE 2005, 'Structural comparison of ligand-binding domains in estrogen-related receptors', Key Engineering Materials, vol. 277-279, no. I, pp. 107-112.
Kim HY, Pae AN, Lee YJ, Park J, Kim DS, Hwang KY et al. Structural comparison of ligand-binding domains in estrogen-related receptors. Key Engineering Materials. 2005 Dec 1;277-279(I):107-112.
Kim, Hye Yeon ; Pae, Ae Nim ; Lee, Yeon Joo ; Park, Joonkyu ; Kim, Dae Sung ; Hwang, Kwang Yeon ; Yu, Myeong Hee ; Kim, Eunice EunKyeong. / Structural comparison of ligand-binding domains in estrogen-related receptors. In: Key Engineering Materials. 2005 ; Vol. 277-279, No. I. pp. 107-112.
@article{22efe0d9ebcd4bdd8cb0bcee7187c266,
title = "Structural comparison of ligand-binding domains in estrogen-related receptors",
abstract = "Estrogen-related receptors (ERRs), orphan nuclear receptors, share a significant amino acid sequence homology with estrogen receptors (ERs), yet their ligands do not respond in the same manner. In fact, some of the ligands that are known as agonists of ERs show antagonistic effect in ERRs. Accordingly, the current study investigated the structures of the ligand-binding domains using homology model building and docking studies. The results showed clear differences between the ligand-binding pockets of ERRs and ERs, thereby providing structural insights into the activities related to the ligands.",
keywords = "4-hydroxyltamoxifen (OHT), Diethylstilbestrol (DES), Estrogen receptor (ER), Estrogen related receptor (ERR), Homology modeling, Ligand-binding domain, Orphan nuclear receptor",
author = "Kim, {Hye Yeon} and Pae, {Ae Nim} and Lee, {Yeon Joo} and Joonkyu Park and Kim, {Dae Sung} and Hwang, {Kwang Yeon} and Yu, {Myeong Hee} and Kim, {Eunice EunKyeong}",
year = "2005",
month = "12",
day = "1",
language = "English",
volume = "277-279",
pages = "107--112",
journal = "Key Engineering Materials",
issn = "1013-9826",
publisher = "Trans Tech Publications",
number = "I",

}

TY - JOUR

T1 - Structural comparison of ligand-binding domains in estrogen-related receptors

AU - Kim, Hye Yeon

AU - Pae, Ae Nim

AU - Lee, Yeon Joo

AU - Park, Joonkyu

AU - Kim, Dae Sung

AU - Hwang, Kwang Yeon

AU - Yu, Myeong Hee

AU - Kim, Eunice EunKyeong

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Estrogen-related receptors (ERRs), orphan nuclear receptors, share a significant amino acid sequence homology with estrogen receptors (ERs), yet their ligands do not respond in the same manner. In fact, some of the ligands that are known as agonists of ERs show antagonistic effect in ERRs. Accordingly, the current study investigated the structures of the ligand-binding domains using homology model building and docking studies. The results showed clear differences between the ligand-binding pockets of ERRs and ERs, thereby providing structural insights into the activities related to the ligands.

AB - Estrogen-related receptors (ERRs), orphan nuclear receptors, share a significant amino acid sequence homology with estrogen receptors (ERs), yet their ligands do not respond in the same manner. In fact, some of the ligands that are known as agonists of ERs show antagonistic effect in ERRs. Accordingly, the current study investigated the structures of the ligand-binding domains using homology model building and docking studies. The results showed clear differences between the ligand-binding pockets of ERRs and ERs, thereby providing structural insights into the activities related to the ligands.

KW - 4-hydroxyltamoxifen (OHT)

KW - Diethylstilbestrol (DES)

KW - Estrogen receptor (ER)

KW - Estrogen related receptor (ERR)

KW - Homology modeling

KW - Ligand-binding domain

KW - Orphan nuclear receptor

UR - http://www.scopus.com/inward/record.url?scp=33646067701&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33646067701&partnerID=8YFLogxK

M3 - Article

VL - 277-279

SP - 107

EP - 112

JO - Key Engineering Materials

JF - Key Engineering Materials

SN - 1013-9826

IS - I

ER -