Structural comparison of zebrafish Elav/Hu and their differential expressions during neurogenesis

Hae Chul Park, Sung Kook Hong, Hyung Seok Kim, Seok Hyung Kim, Eun Ja Yoon, Cheol Hee Kim, Naomasa Miki, Tae Lin Huh

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

The present communication reports the isolation and characterization of three new zebrafish elav/Hu (Kim, C.-H., Ueshima, E., Muraoka, O., Tanaka, H., Yeo, S.-Y., Huh, T.-L. and Miki, N., Zebrafish elav/HuC homologue as a very early neuronal marker. Neurosci. Lett., 216 (1996) 109-112) homologues, HuA, HuD and HuG. While HuA and HuG showed weak and ubiquitous expressions, HuD, as well as HuC, were specifically expressed in the neuronal cells. The first expression of HuD was detectable of the 10-somite stage, that is, several hours later than HuC. After 24 h of embryonic development, although HuD and HuC expressions overlapped overall, the cells expressing HuD were restricted to subsets of the HuC-positive neuronal cells in the brain and spinal cord. These differentially regulated spatial and temporal expression patterns implied distinct roles for HuC and HuD in neuronal determination and neuronal differentiation, respectively. Copyright (C) 2000 Elsevier Science Ireland Ltd.

Original languageEnglish
Pages (from-to)81-84
Number of pages4
JournalNeuroscience Letters
Volume279
Issue number2
DOIs
Publication statusPublished - 2000 Jan 28
Externally publishedYes

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Neurogenesis
Zebrafish
Somites
Embryonic Development
Spinal Cord
Brain

Keywords

  • HuA
  • HuC
  • HuD
  • HuG
  • Neural plate
  • Neuronal determination
  • Neuronal differentiation
  • Zebrafish

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Structural comparison of zebrafish Elav/Hu and their differential expressions during neurogenesis. / Park, Hae Chul; Hong, Sung Kook; Kim, Hyung Seok; Kim, Seok Hyung; Yoon, Eun Ja; Kim, Cheol Hee; Miki, Naomasa; Huh, Tae Lin.

In: Neuroscience Letters, Vol. 279, No. 2, 28.01.2000, p. 81-84.

Research output: Contribution to journalArticle

Park, Hae Chul ; Hong, Sung Kook ; Kim, Hyung Seok ; Kim, Seok Hyung ; Yoon, Eun Ja ; Kim, Cheol Hee ; Miki, Naomasa ; Huh, Tae Lin. / Structural comparison of zebrafish Elav/Hu and their differential expressions during neurogenesis. In: Neuroscience Letters. 2000 ; Vol. 279, No. 2. pp. 81-84.
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