Abstract
Many cyclic peptides and analogues derived from marine sources are known to possess biological properties, including anticancer, antitumor, antibacterial, antifungal, antiparasitic, anti-inflammation, anti-proliferative, anti-hypertensive, cytotoxic, and antibiotic properties. These compounds demonstrate different activities and modes of action according to their structure such as cyclic oligopeptide, cyclic lipopeptide, cyclic glycopeptide and cyclic depsipeptide. The recent advances in application of the above-mentioned cyclic peptides were reported in dolastatins, soblidotin, didemnin B, aplidine, salinosporamide A, kahalalide F and bryostatin 1 and they are currently in clinical trials. These cyclic peptides are possible novel drugs discovered and developed from marine origin. Literature data concerning the potential properties of marine cyclic peptides were reviewed here, and the structural diversity and biological activities of marine cyclic peptides are discussed in relation to the molecular mechanisms of these marine cyclic peptides.
| Original language | English |
|---|---|
| Pages (from-to) | 94-105 |
| Number of pages | 12 |
| Journal | Peptides |
| Volume | 95 |
| DOIs | |
| Publication status | Published - 2017 Sep 1 |
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Keywords
- Antibacterial
- Anticancer
- Antifungal
- Cyclic peptides
- Marine organism
ASJC Scopus subject areas
- Physiology
- Biochemistry
- Endocrinology
- Cellular and Molecular Neuroscience
Cite this
Structural diversity of marine cyclic peptides and their molecular mechanisms for anticancer, antibacterial, antifungal, and other clinical applications. / Lee, Yeji; Phat, Chanvorleak; Hong, Soon Cheol.
In: Peptides, Vol. 95, 01.09.2017, p. 94-105.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Structural diversity of marine cyclic peptides and their molecular mechanisms for anticancer, antibacterial, antifungal, and other clinical applications
AU - Lee, Yeji
AU - Phat, Chanvorleak
AU - Hong, Soon Cheol
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Many cyclic peptides and analogues derived from marine sources are known to possess biological properties, including anticancer, antitumor, antibacterial, antifungal, antiparasitic, anti-inflammation, anti-proliferative, anti-hypertensive, cytotoxic, and antibiotic properties. These compounds demonstrate different activities and modes of action according to their structure such as cyclic oligopeptide, cyclic lipopeptide, cyclic glycopeptide and cyclic depsipeptide. The recent advances in application of the above-mentioned cyclic peptides were reported in dolastatins, soblidotin, didemnin B, aplidine, salinosporamide A, kahalalide F and bryostatin 1 and they are currently in clinical trials. These cyclic peptides are possible novel drugs discovered and developed from marine origin. Literature data concerning the potential properties of marine cyclic peptides were reviewed here, and the structural diversity and biological activities of marine cyclic peptides are discussed in relation to the molecular mechanisms of these marine cyclic peptides.
AB - Many cyclic peptides and analogues derived from marine sources are known to possess biological properties, including anticancer, antitumor, antibacterial, antifungal, antiparasitic, anti-inflammation, anti-proliferative, anti-hypertensive, cytotoxic, and antibiotic properties. These compounds demonstrate different activities and modes of action according to their structure such as cyclic oligopeptide, cyclic lipopeptide, cyclic glycopeptide and cyclic depsipeptide. The recent advances in application of the above-mentioned cyclic peptides were reported in dolastatins, soblidotin, didemnin B, aplidine, salinosporamide A, kahalalide F and bryostatin 1 and they are currently in clinical trials. These cyclic peptides are possible novel drugs discovered and developed from marine origin. Literature data concerning the potential properties of marine cyclic peptides were reviewed here, and the structural diversity and biological activities of marine cyclic peptides are discussed in relation to the molecular mechanisms of these marine cyclic peptides.
KW - Antibacterial
KW - Anticancer
KW - Antifungal
KW - Cyclic peptides
KW - Marine organism
UR - http://www.scopus.com/inward/record.url?scp=85026821585&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85026821585&partnerID=8YFLogxK
U2 - 10.1016/j.peptides.2017.06.002
DO - 10.1016/j.peptides.2017.06.002
M3 - Review article
C2 - 28610952
AN - SCOPUS:85026821585
VL - 95
SP - 94
EP - 105
JO - Peptides
JF - Peptides
SN - 0196-9781
ER -