Structural diversity of marine cyclic peptides and their molecular mechanisms for anticancer, antibacterial, antifungal, and other clinical applications

Yeji Lee, Chanvorleak Phat, Soon Cheol Hong

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

Many cyclic peptides and analogues derived from marine sources are known to possess biological properties, including anticancer, antitumor, antibacterial, antifungal, antiparasitic, anti-inflammation, anti-proliferative, anti-hypertensive, cytotoxic, and antibiotic properties. These compounds demonstrate different activities and modes of action according to their structure such as cyclic oligopeptide, cyclic lipopeptide, cyclic glycopeptide and cyclic depsipeptide. The recent advances in application of the above-mentioned cyclic peptides were reported in dolastatins, soblidotin, didemnin B, aplidine, salinosporamide A, kahalalide F and bryostatin 1 and they are currently in clinical trials. These cyclic peptides are possible novel drugs discovered and developed from marine origin. Literature data concerning the potential properties of marine cyclic peptides were reviewed here, and the structural diversity and biological activities of marine cyclic peptides are discussed in relation to the molecular mechanisms of these marine cyclic peptides.

Original languageEnglish
Pages (from-to)94-105
Number of pages12
JournalPeptides
Volume95
DOIs
Publication statusPublished - 2017 Sep 1

Fingerprint

Cyclic Peptides
didemnins
Antineoplastic Antibiotics
Depsipeptides
Lipopeptides
Antiparasitic Agents
Oligopeptides
Glycopeptides
Biodiversity
Bioactivity
Antihypertensive Agents
Clinical Trials
Inflammation
Pharmaceutical Preparations

Keywords

  • Antibacterial
  • Anticancer
  • Antifungal
  • Cyclic peptides
  • Marine organism

ASJC Scopus subject areas

  • Physiology
  • Biochemistry
  • Endocrinology
  • Cellular and Molecular Neuroscience

Cite this

Structural diversity of marine cyclic peptides and their molecular mechanisms for anticancer, antibacterial, antifungal, and other clinical applications. / Lee, Yeji; Phat, Chanvorleak; Hong, Soon Cheol.

In: Peptides, Vol. 95, 01.09.2017, p. 94-105.

Research output: Contribution to journalReview article

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