Structural Reorganization and Fibrinogen Adsorption Behaviors on the Polyrotaxane Surfaces Investigated by Sum Frequency Generation Spectroscopy

Aimin Ge, Ji-Hun Seo, Lin Qiao, Nobuhiko Yui, Shen Ye

Research output: Contribution to journalArticle

5 Citations (Scopus)


Polyrotaxanes, such as supramolecular assemblies with methylated α-cyclodextrins (α-CDs) as host molecules noncovalently threaded on the linear polymer backbone, are promising materials for biomedical applications because they allow adsorbed proteins possessing a high surface flexibility as well as control of the cellular morphology and adhesion. To provide a general design principle for biomedical materials, we examined the surface reorganization behaviors and adsorption conformations of fibrinogen on the polyrotaxane surfaces with comparison to several random copolymers by sum frequency generation (SFG) vibrational spectroscopy. We showed that the polyrotaxane (OMe-PRX-PMB) with methylated α-CDs as the host molecule exhibited unique surface structures in an aqueous environment. The hydrophobic interaction between the methoxy groups of the methylated α-CD molecules and methyl groups of the n-butyl methacrylate (BMA) side chains may dominate the surface restructuring behavior of the OMe-PRX-PMB. The orientation analysis revealed that the orientation of the fibrinogen adsorbed on the OMe-PRX-PMB surface is close to a single distribution, which is different from the adsorption behaviors of fibrinogen on other polyrotaxane or random copolymer surfaces.

Original languageEnglish
Pages (from-to)22709-22718
Number of pages10
JournalACS Applied Materials and Interfaces
Issue number40
Publication statusPublished - 2015 Oct 14
Externally publishedYes



  • biomedical materials
  • fibrinogen adsorption
  • polyrotaxane
  • SFG vibrational spectroscopy
  • surface reorganization
  • α-cyclodextrin (α-CD)

ASJC Scopus subject areas

  • Materials Science(all)

Cite this