Structure of OsmC from Escherichia coli

A salt-shock-induced protein

Dong Hae Shin, In-Geol Choi, Didier Busso, Jaru Jancarik, Hisao Yokota, Rosalind Kim, Sung Hou Kim

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

The crystal structure of an osmotically inducible protein (OsmC) from Escherichia coli has been determined at 2.4 Å resolution. OsmC is a representative protein of the OsmC sequence family, which is composed of three sequence subfamilies. The structure of OsmC provides a view of a salt-shock-induced protein. Two identical monomers form a cylindrically shaped dimer in which six helices are located on the inside and two six-stranded β-sheets wrap around these helices. Structural comparison suggests that the OsmC sequence family has a peroxiredoxin function and has a unique structure compared with other peroxiredoxin families. A detailed analysis of structures and sequence comparisons in the OsmC sequence family revealed that each subfamily has unique motifs. In addition, the molecular function of the OsmC sequence family is discussed based on structural comparisons among the subfamily members.

Original languageEnglish
Pages (from-to)903-911
Number of pages9
JournalActa Crystallographica Section D: Biological Crystallography
Volume60
Issue number5
DOIs
Publication statusPublished - 2004 May 1
Externally publishedYes

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Peroxiredoxins
Escherichia
Escherichia coli
Shock
Salts
shock
salts
proteins
helices
Escherichia coli Proteins
Sequence Analysis
wrap
Proteins
Dimers
monomers
Monomers
Crystal structure
dimers
crystal structure

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Biophysics
  • Condensed Matter Physics
  • Structural Biology

Cite this

Structure of OsmC from Escherichia coli : A salt-shock-induced protein. / Shin, Dong Hae; Choi, In-Geol; Busso, Didier; Jancarik, Jaru; Yokota, Hisao; Kim, Rosalind; Kim, Sung Hou.

In: Acta Crystallographica Section D: Biological Crystallography, Vol. 60, No. 5, 01.05.2004, p. 903-911.

Research output: Contribution to journalArticle

Shin, Dong Hae ; Choi, In-Geol ; Busso, Didier ; Jancarik, Jaru ; Yokota, Hisao ; Kim, Rosalind ; Kim, Sung Hou. / Structure of OsmC from Escherichia coli : A salt-shock-induced protein. In: Acta Crystallographica Section D: Biological Crystallography. 2004 ; Vol. 60, No. 5. pp. 903-911.
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