Structure-Property Relationships of 3D-Printable Chain-Extended Block Copolymers with Tunable Elasticity and Biodegradability

Ryung Il Kim; Geonchang Lee; Jung Hyun Lee; Ji Jong Park; Albert S. Lee; Seung Sang Hwang

doi:10.1021/acsapm.1c00860

Structure-Property Relationships of 3D-Printable Chain-Extended Block Copolymers with Tunable Elasticity and Biodegradability

Ryung Il Kim, Geonchang Lee, Jung Hyun Lee, Ji Jong Park, Albert S. Lee, Seung Sang Hwang

Department of Chemical and Biological Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

Elastomeric bioscaffolds with tunable elasticity and biodegradability were synthesized via ring opening polymerization of polycaprolactone (PCL) and polylactide (PLA) with a bifunctional polyethylene glycol macroinitiator, followed by chain extension with diisocyanate to form urethane linkages. Through fine tuning of the macroinitiator and PCL/PLA weight fraction and molecular weight, a data set of elastomeric bioscaffolds gives structure-property insights into their thermal, mechanical, and biodegradability properties as they relate to triblock copolymer composition and mechanical weight. These materials were targeted to be 3D-printed by commercial devices, and their unique rheological properties enable impeccable multiscale microstructure formation. Simplicity in synthesis and fabrication as well as tunable biodegradability (1 day to 2 months) and elasticity (modulus 32-94 MPa) suggest the vast wide-ranging utility and prospective application in bioscaffolds for future therapeutic treatments.

Original language	English
Pages (from-to)	4708-4716
Number of pages	9
Journal	ACS Applied Polymer Materials
Volume	3
Issue number	9
DOIs	https://doi.org/10.1021/acsapm.1c00860
Publication status	Published - 2021 Sep 10

Keywords

3D printing
biodegradable polymers
bioelastomer
block copolymer
polyurethane

ASJC Scopus subject areas

Polymers and Plastics
Process Chemistry and Technology
Organic Chemistry

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10.1021/acsapm.1c00860

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title = "Structure-Property Relationships of 3D-Printable Chain-Extended Block Copolymers with Tunable Elasticity and Biodegradability",

abstract = "Elastomeric bioscaffolds with tunable elasticity and biodegradability were synthesized via ring opening polymerization of polycaprolactone (PCL) and polylactide (PLA) with a bifunctional polyethylene glycol macroinitiator, followed by chain extension with diisocyanate to form urethane linkages. Through fine tuning of the macroinitiator and PCL/PLA weight fraction and molecular weight, a data set of elastomeric bioscaffolds gives structure-property insights into their thermal, mechanical, and biodegradability properties as they relate to triblock copolymer composition and mechanical weight. These materials were targeted to be 3D-printed by commercial devices, and their unique rheological properties enable impeccable multiscale microstructure formation. Simplicity in synthesis and fabrication as well as tunable biodegradability (1 day to 2 months) and elasticity (modulus 32-94 MPa) suggest the vast wide-ranging utility and prospective application in bioscaffolds for future therapeutic treatments. ",

keywords = "3D printing, biodegradable polymers, bioelastomer, block copolymer, polyurethane",

author = "Kim, {Ryung Il} and Geonchang Lee and Lee, {Jung Hyun} and Park, {Ji Jong} and Lee, {Albert S.} and Hwang, {Seung Sang}",

note = "Funding Information: This work was supported by the Fundamental R&D Program for Core Technology of Materials and the Industrial Strategic Technology Development Program funded by the Ministry of Trade, Industry and Energy, Republic of Korea [20008734], the National R&D Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT [2018M3A9E2023257], and the institutional program of the Materials Architecturing Research Center of Korea Institute of Science and Technology. Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",

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doi = "10.1021/acsapm.1c00860",

language = "English",

volume = "3",

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journal = "ACS Applied Polymer Materials",

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AU - Kim, Ryung Il

AU - Lee, Geonchang

AU - Lee, Jung Hyun

AU - Park, Ji Jong

AU - Lee, Albert S.

AU - Hwang, Seung Sang

N1 - Funding Information: This work was supported by the Fundamental R&D Program for Core Technology of Materials and the Industrial Strategic Technology Development Program funded by the Ministry of Trade, Industry and Energy, Republic of Korea [20008734], the National R&D Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science and ICT [2018M3A9E2023257], and the institutional program of the Materials Architecturing Research Center of Korea Institute of Science and Technology. Publisher Copyright: © 2021 American Chemical Society.

PY - 2021/9/10

Y1 - 2021/9/10

N2 - Elastomeric bioscaffolds with tunable elasticity and biodegradability were synthesized via ring opening polymerization of polycaprolactone (PCL) and polylactide (PLA) with a bifunctional polyethylene glycol macroinitiator, followed by chain extension with diisocyanate to form urethane linkages. Through fine tuning of the macroinitiator and PCL/PLA weight fraction and molecular weight, a data set of elastomeric bioscaffolds gives structure-property insights into their thermal, mechanical, and biodegradability properties as they relate to triblock copolymer composition and mechanical weight. These materials were targeted to be 3D-printed by commercial devices, and their unique rheological properties enable impeccable multiscale microstructure formation. Simplicity in synthesis and fabrication as well as tunable biodegradability (1 day to 2 months) and elasticity (modulus 32-94 MPa) suggest the vast wide-ranging utility and prospective application in bioscaffolds for future therapeutic treatments.

AB - Elastomeric bioscaffolds with tunable elasticity and biodegradability were synthesized via ring opening polymerization of polycaprolactone (PCL) and polylactide (PLA) with a bifunctional polyethylene glycol macroinitiator, followed by chain extension with diisocyanate to form urethane linkages. Through fine tuning of the macroinitiator and PCL/PLA weight fraction and molecular weight, a data set of elastomeric bioscaffolds gives structure-property insights into their thermal, mechanical, and biodegradability properties as they relate to triblock copolymer composition and mechanical weight. These materials were targeted to be 3D-printed by commercial devices, and their unique rheological properties enable impeccable multiscale microstructure formation. Simplicity in synthesis and fabrication as well as tunable biodegradability (1 day to 2 months) and elasticity (modulus 32-94 MPa) suggest the vast wide-ranging utility and prospective application in bioscaffolds for future therapeutic treatments.

KW - 3D printing

KW - biodegradable polymers

KW - bioelastomer

KW - block copolymer

KW - polyurethane

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Structure-Property Relationships of 3D-Printable Chain-Extended Block Copolymers with Tunable Elasticity and Biodegradability

Abstract

Keywords

ASJC Scopus subject areas

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