Studies on the synthesis and in vitro antitumor activity of the isoquinolone derivatives

Seung Hoon Cheon, Joon Yeol Lee, Byung Ho Chung, Bo Gil Choi, Won Jea Cho, Tae Sung Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

3-Arylisoquinolin-1(2H)-ones (2) are possible bioisosteres of the 5-[4′-(piperidinomethyl)phenyl]-2,3-dihydroimidazo[2,1-a]isoquinoline (1) which is in clinical evaluation for the treatment of cancer. Structure-activity relationship studies of 3-arylisoquinolin-1(2H)-ones (2) led to the synthesis of 3-arylquinolin-2(1H)-ones (3). A number of 3-phenyl substituted quinolin-2(1H)-ones were synthesized and tested for their in vitro antitumor activity against four different human tumor cell lines and 3-phenyl-N-benzyl-3,4-dihydroquinolin-2(1H)-one (12) showed the most potent activity.

Original languageEnglish
Pages (from-to)179-183
Number of pages5
JournalArchives of Pharmacal Research
Volume22
Issue number2
Publication statusPublished - 1999 Apr 1

Keywords

  • 3-Arylisoquinolin-1-ones
  • 3-Arylquinolin-2-ones
  • Antitumor
  • Cytotoxicity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

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    Cheon, S. H., Lee, J. Y., Chung, B. H., Choi, B. G., Cho, W. J., & Kim, T. S. (1999). Studies on the synthesis and in vitro antitumor activity of the isoquinolone derivatives. Archives of Pharmacal Research, 22(2), 179-183.