Study of artemisinin nanocapsules as anticancer drug delivery systems

Youfang Chen, Xianfu Lin, Hyunjin Park, Richard Greever

Research output: Contribution to journalArticle

84 Citations (Scopus)

Abstract

Artemisinin (ART) crystals were encapsulated with chitosan, gelatin, and alginate for the purpose of controlled release. These polyelectrolytes were alternatively deposited on ART crystals sized about 766 nm through the layer-by-layer technique. Size distribution, zeta potential, and swelling property of ART nanocapsules were measured. The morphology of ART nanocapsules was observed by transmission electron microscopy after dissolution. Release property of ART nanocapsules was measured in phosphate buffer solution (pH 7.4). It was proved that the ART nanocapsules dispersed well in aqueous solutions. Hydrophilicity of ART crystals was improved after encapsulation. The ART drug release rate was tuned by the properties of polyelectrolyte solutions, such as polyelectrolyte type, number of polyelectrolyte multilayers, sodium chloride concentration, and ethanol concentration in polyelectrolyte solution, and so on. Our research provides a feasible method of achieving prolonged drug release through self-assembly of polyelectrolytes on natural drug crystals. From the Clinical Editor: Artemisinin (ART) crystals were encapsulated with chitosan, gelatin, and alginate for the purpose of controlled release of this anticancer drug. The reported method is feasible for achieving prolonged drug release through self-assembly of polyelectroytes on natural drug crystals.

Original languageEnglish
Pages (from-to)316-322
Number of pages7
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume5
Issue number3
DOIs
Publication statusPublished - 2009 Sep

Keywords

  • Artemisinin
  • Controlled release
  • Nanoencapsulation

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

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