Studying Water Hydrogen-Bonding Network near the Lipid Multibilayer with Multiple IR Probes

Achintya Kundu, Pramod Kumar Verma, Jeong Hyon Ha, Minhaeng Cho

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

A critical difference between living and nonliving is the existence of cell membranes, and hydration of membrane surface is a prerequisite for structural stability and various functions such as absorption/desorption of drugs, proteins, and ions. Therefore, a molecular level understanding of water structure and dynamics near the membrane is important to perceive the role of water in such a biologically relevant environment. In our recent paper [ J. Phys. Chem. Lett. 2016, 7, 741 ] on the IR pump-probe study of the OD stretch mode of HDO near lipid multibilayers, we have observed two different vibrational lifetime components of OD stretch mode in the phospholipid multibilayer systems. The faster component (0.6 ps) is associated with OD groups interacting with the phosphate moiety of the lipid, while the slower component (1.9 ps) is due to choline-associated water molecules that are close to bulklike water. Here, we additionally use hydrazoic acid (HN3) as another IR probe of which frequency is highly sensitive to its local H-bonding water density. Interestingly, we found that the vibrational lifetime of the asymmetric azido stretch mode of HN3 in the lipid multibilayer system is similar to that in neat water, whereas its orientational relaxation is a bit slower than that in bulk water. This indicates that due to the tight packing of lipid molecules, particularly the head parts, in the gel phase, HN3 molecules mostly stay near the choline group of lipid and interact with water molecules in the vicinity of choline groups. This suggests that membrane surface-adsorbed molecules such as hydrophilic drug molecules may interact with choline-associated water molecules, when the membrane is in the gel phase, instead of phosphate-associated water molecules.

Original languageEnglish
Pages (from-to)1435-1441
Number of pages7
JournalJournal of Physical Chemistry A
Volume121
Issue number7
DOIs
Publication statusPublished - 2017 Feb 23

Fingerprint

Hydrogen Bonding
lipids
Hydrogen bonds
Lipids
Water
probes
hydrogen
choline
Molecules
water
Choline
molecules
membranes
Membranes
phosphates
drugs
hydrazoic acid
Gels
Phosphates
gels

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry

Cite this

Studying Water Hydrogen-Bonding Network near the Lipid Multibilayer with Multiple IR Probes. / Kundu, Achintya; Verma, Pramod Kumar; Ha, Jeong Hyon; Cho, Minhaeng.

In: Journal of Physical Chemistry A, Vol. 121, No. 7, 23.02.2017, p. 1435-1441.

Research output: Contribution to journalArticle

Kundu, Achintya ; Verma, Pramod Kumar ; Ha, Jeong Hyon ; Cho, Minhaeng. / Studying Water Hydrogen-Bonding Network near the Lipid Multibilayer with Multiple IR Probes. In: Journal of Physical Chemistry A. 2017 ; Vol. 121, No. 7. pp. 1435-1441.
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