Subcortical grey matter changes in juvenile myoclonic epilepsy

Ji Hyun Kim, Jung Bin Kim, Sang-Il Suh, Dong Wook Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Recent neuroimaging studies have provided converging evidence of structural and functional abnormalities of the thalamus in patients with juvenile myoclonic epilepsy (JME). There has also been limited evidence indicating involvement of the subcortical grey matter structures other than thalamus in JME, but with inconsistent findings across the studies. In the present study, we combined volumetric MRI and diffusion tensor imaging analyses to investigate macrostructural and microstructural alterations of the subcortical grey matter in 64 JME patients compared to 58 matched control subjects. Raw volume, fractional anisotropy (FA), and mean diffusivity (MD) of 6 subcortical grey matter structures (amygdala, hippocampus, caudate, pallidum, putamen, thalamus) were measured in both hemispheres. Between-group (controls versus patients) comparisons of normalized volume, FA, and MD, as well as within-group (patients) correlation analyses between structural changes and clinical variables were carried out. Compared to controls, JME patients exhibited significant volume reductions in left pallidum and bilateral putamen and thalamus. Duration of epilepsy negatively correlated with bilateral putamen volumes. Patients and controls did not differ in FA values of all structures. Compared to controls, JME patients showed significant MD increases in left pallidum and bilateral hippocampus, putamen, and thalamus. Significant positive correlations were found between duration of epilepsy and MD values of bilateral hippocampus and thalamus. We have provided evidence that macrostructural and microstructural abnormalities may not only be confined to the thalamus but also affect basal ganglia and hippocampus in JME. Our findings could further support the pathophysiological hypothesis of striato-thalamo-frontal network abnormality underlying JME, and may implicate disease progression.

Original languageEnglish
Pages (from-to)397-404
Number of pages8
JournalNeuroImage: Clinical
Volume17
DOIs
Publication statusPublished - 2018 Jan 1

Fingerprint

Juvenile Myoclonic Epilepsy
Thalamus
Putamen
Globus Pallidus
Hippocampus
Anisotropy
Epilepsy
Diffusion Tensor Imaging
Gray Matter
Amygdala
Basal Ganglia
Neuroimaging
Disease Progression
Control Groups

Keywords

  • Basal ganglia
  • Fractional anisotropy
  • Hippocampus
  • Juvenile myoclonic epilepsy
  • Mean diffusivity
  • Thalamus
  • Volumetry

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Neurology
  • Clinical Neurology
  • Cognitive Neuroscience

Cite this

Subcortical grey matter changes in juvenile myoclonic epilepsy. / Kim, Ji Hyun; Kim, Jung Bin; Suh, Sang-Il; Kim, Dong Wook.

In: NeuroImage: Clinical, Vol. 17, 01.01.2018, p. 397-404.

Research output: Contribution to journalArticle

Kim, Ji Hyun ; Kim, Jung Bin ; Suh, Sang-Il ; Kim, Dong Wook. / Subcortical grey matter changes in juvenile myoclonic epilepsy. In: NeuroImage: Clinical. 2018 ; Vol. 17. pp. 397-404.
@article{d5bd2fa5468b48d6b98c6de94a3be472,
title = "Subcortical grey matter changes in juvenile myoclonic epilepsy",
abstract = "Recent neuroimaging studies have provided converging evidence of structural and functional abnormalities of the thalamus in patients with juvenile myoclonic epilepsy (JME). There has also been limited evidence indicating involvement of the subcortical grey matter structures other than thalamus in JME, but with inconsistent findings across the studies. In the present study, we combined volumetric MRI and diffusion tensor imaging analyses to investigate macrostructural and microstructural alterations of the subcortical grey matter in 64 JME patients compared to 58 matched control subjects. Raw volume, fractional anisotropy (FA), and mean diffusivity (MD) of 6 subcortical grey matter structures (amygdala, hippocampus, caudate, pallidum, putamen, thalamus) were measured in both hemispheres. Between-group (controls versus patients) comparisons of normalized volume, FA, and MD, as well as within-group (patients) correlation analyses between structural changes and clinical variables were carried out. Compared to controls, JME patients exhibited significant volume reductions in left pallidum and bilateral putamen and thalamus. Duration of epilepsy negatively correlated with bilateral putamen volumes. Patients and controls did not differ in FA values of all structures. Compared to controls, JME patients showed significant MD increases in left pallidum and bilateral hippocampus, putamen, and thalamus. Significant positive correlations were found between duration of epilepsy and MD values of bilateral hippocampus and thalamus. We have provided evidence that macrostructural and microstructural abnormalities may not only be confined to the thalamus but also affect basal ganglia and hippocampus in JME. Our findings could further support the pathophysiological hypothesis of striato-thalamo-frontal network abnormality underlying JME, and may implicate disease progression.",
keywords = "Basal ganglia, Fractional anisotropy, Hippocampus, Juvenile myoclonic epilepsy, Mean diffusivity, Thalamus, Volumetry",
author = "Kim, {Ji Hyun} and Kim, {Jung Bin} and Sang-Il Suh and Kim, {Dong Wook}",
year = "2018",
month = "1",
day = "1",
doi = "10.1016/j.nicl.2017.11.001",
language = "English",
volume = "17",
pages = "397--404",
journal = "NeuroImage: Clinical",
issn = "2213-1582",
publisher = "Elsevier BV",

}

TY - JOUR

T1 - Subcortical grey matter changes in juvenile myoclonic epilepsy

AU - Kim, Ji Hyun

AU - Kim, Jung Bin

AU - Suh, Sang-Il

AU - Kim, Dong Wook

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Recent neuroimaging studies have provided converging evidence of structural and functional abnormalities of the thalamus in patients with juvenile myoclonic epilepsy (JME). There has also been limited evidence indicating involvement of the subcortical grey matter structures other than thalamus in JME, but with inconsistent findings across the studies. In the present study, we combined volumetric MRI and diffusion tensor imaging analyses to investigate macrostructural and microstructural alterations of the subcortical grey matter in 64 JME patients compared to 58 matched control subjects. Raw volume, fractional anisotropy (FA), and mean diffusivity (MD) of 6 subcortical grey matter structures (amygdala, hippocampus, caudate, pallidum, putamen, thalamus) were measured in both hemispheres. Between-group (controls versus patients) comparisons of normalized volume, FA, and MD, as well as within-group (patients) correlation analyses between structural changes and clinical variables were carried out. Compared to controls, JME patients exhibited significant volume reductions in left pallidum and bilateral putamen and thalamus. Duration of epilepsy negatively correlated with bilateral putamen volumes. Patients and controls did not differ in FA values of all structures. Compared to controls, JME patients showed significant MD increases in left pallidum and bilateral hippocampus, putamen, and thalamus. Significant positive correlations were found between duration of epilepsy and MD values of bilateral hippocampus and thalamus. We have provided evidence that macrostructural and microstructural abnormalities may not only be confined to the thalamus but also affect basal ganglia and hippocampus in JME. Our findings could further support the pathophysiological hypothesis of striato-thalamo-frontal network abnormality underlying JME, and may implicate disease progression.

AB - Recent neuroimaging studies have provided converging evidence of structural and functional abnormalities of the thalamus in patients with juvenile myoclonic epilepsy (JME). There has also been limited evidence indicating involvement of the subcortical grey matter structures other than thalamus in JME, but with inconsistent findings across the studies. In the present study, we combined volumetric MRI and diffusion tensor imaging analyses to investigate macrostructural and microstructural alterations of the subcortical grey matter in 64 JME patients compared to 58 matched control subjects. Raw volume, fractional anisotropy (FA), and mean diffusivity (MD) of 6 subcortical grey matter structures (amygdala, hippocampus, caudate, pallidum, putamen, thalamus) were measured in both hemispheres. Between-group (controls versus patients) comparisons of normalized volume, FA, and MD, as well as within-group (patients) correlation analyses between structural changes and clinical variables were carried out. Compared to controls, JME patients exhibited significant volume reductions in left pallidum and bilateral putamen and thalamus. Duration of epilepsy negatively correlated with bilateral putamen volumes. Patients and controls did not differ in FA values of all structures. Compared to controls, JME patients showed significant MD increases in left pallidum and bilateral hippocampus, putamen, and thalamus. Significant positive correlations were found between duration of epilepsy and MD values of bilateral hippocampus and thalamus. We have provided evidence that macrostructural and microstructural abnormalities may not only be confined to the thalamus but also affect basal ganglia and hippocampus in JME. Our findings could further support the pathophysiological hypothesis of striato-thalamo-frontal network abnormality underlying JME, and may implicate disease progression.

KW - Basal ganglia

KW - Fractional anisotropy

KW - Hippocampus

KW - Juvenile myoclonic epilepsy

KW - Mean diffusivity

KW - Thalamus

KW - Volumetry

UR - http://www.scopus.com/inward/record.url?scp=85033399901&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85033399901&partnerID=8YFLogxK

U2 - 10.1016/j.nicl.2017.11.001

DO - 10.1016/j.nicl.2017.11.001

M3 - Article

C2 - 29159052

AN - SCOPUS:85033399901

VL - 17

SP - 397

EP - 404

JO - NeuroImage: Clinical

JF - NeuroImage: Clinical

SN - 2213-1582

ER -