Subcortical grey matter changes in untreated, early stage Parkinson's disease without dementia

Hye Mi Lee, Kyum Yil Kwon, Min Jik Kim, Ji Wan Jang, Sang-Il Suh, Seong Beom Koh, Ji Hyun Kim

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Background: Previous MRI studies have investigated cortical or subcortical grey matter changes in patients with Parkinson's disease (PD), yielding inconsistent findings between the studies. We therefore sought to determine whether focal cortical or subcortical grey matter changes may be present from the early disease stage. Methods: We recruited 49 untreated, early stage PD patients without dementia and 53 control subjects. Voxel-based morphometry was used to evaluate cortical grey matter changes, and automated volumetry and shape analysis were used to assess volume changes and shape deformation of the subcortical grey matter structures, respectively. Results: Voxel-based morphometry showed neither reductions nor increases in grey matter volume in patients compared to controls. Compared to controls, PD patients had significant reductions in adjusted volumes of putamen, nucleus accumbens, and hippocampus (corrected p < 0.05). Vertex-based shape analysis showed regionally contracted area on the posterolateral and ventromedial putamen bilaterally in PD patients (corrected p < 0.05). No correlations were found between cortical and subcortical grey matter and clinical variables representing disease duration and severity. Conclusions: Our results suggest that untreated, early stage PD without dementia is associated with volume reduction and shape deformation of subcortical grey matter, but not with cortical grey matter reduction. Our findings of structural changes in the posterolateral putamen and ventromedial putamen/nucleus accumbens could provide neuroanatomical basis for the involvement of motor and limbic striatum, further implicating motor and non-motor symptoms in PD, respectively. Early hippocampal involvement might be related to the risk for developing dementia in PD patients.

Original languageEnglish
Pages (from-to)622-626
Number of pages5
JournalParkinsonism and Related Disorders
Volume20
Issue number6
DOIs
Publication statusPublished - 2014 Jan 1

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Parkinson Disease
Dementia
Putamen
Nucleus Accumbens
Gray Matter
Hippocampus

Keywords

  • Parkinson's disease
  • Regional volumetry
  • Shape analysis
  • Subcortical grey matter
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Subcortical grey matter changes in untreated, early stage Parkinson's disease without dementia. / Lee, Hye Mi; Kwon, Kyum Yil; Kim, Min Jik; Jang, Ji Wan; Suh, Sang-Il; Koh, Seong Beom; Kim, Ji Hyun.

In: Parkinsonism and Related Disorders, Vol. 20, No. 6, 01.01.2014, p. 622-626.

Research output: Contribution to journalArticle

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AB - Background: Previous MRI studies have investigated cortical or subcortical grey matter changes in patients with Parkinson's disease (PD), yielding inconsistent findings between the studies. We therefore sought to determine whether focal cortical or subcortical grey matter changes may be present from the early disease stage. Methods: We recruited 49 untreated, early stage PD patients without dementia and 53 control subjects. Voxel-based morphometry was used to evaluate cortical grey matter changes, and automated volumetry and shape analysis were used to assess volume changes and shape deformation of the subcortical grey matter structures, respectively. Results: Voxel-based morphometry showed neither reductions nor increases in grey matter volume in patients compared to controls. Compared to controls, PD patients had significant reductions in adjusted volumes of putamen, nucleus accumbens, and hippocampus (corrected p < 0.05). Vertex-based shape analysis showed regionally contracted area on the posterolateral and ventromedial putamen bilaterally in PD patients (corrected p < 0.05). No correlations were found between cortical and subcortical grey matter and clinical variables representing disease duration and severity. Conclusions: Our results suggest that untreated, early stage PD without dementia is associated with volume reduction and shape deformation of subcortical grey matter, but not with cortical grey matter reduction. Our findings of structural changes in the posterolateral putamen and ventromedial putamen/nucleus accumbens could provide neuroanatomical basis for the involvement of motor and limbic striatum, further implicating motor and non-motor symptoms in PD, respectively. Early hippocampal involvement might be related to the risk for developing dementia in PD patients.

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