Korean Source BKorean Source BKorean Source

Translated title of the contribution: Subgenotype and serotype analysis of hepatitis B virus in Korean chronic hepatitis B patients under treatment

Choong Hwan Cha, Yong Hak Sohn, Sun-Young Ko, Heung Bum Oh

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Hepatitis B virus (HBV) detected in Korean patients almost belongs to genotype C, which is subdivided into subgenotype C1 (or Cs) and C2 (or Ce). It was recently reported that the risk of hepatocellular carcinoma is different between subgenotype C1 and C2. Thus, we studied the distribution of subgenotypes of HBV in Korean chronic hepatitis B (CHB) patients. Methods: Specimens of 421 patients, who were diagnosed as CHB and underwent antiviral treatment, were used. After sequence analysis for HBV S gene, subgenotype was identified through phylogenetic analysis. Utilizing the same sequence data, the distribution of serotypes was also investigated. Results: Among 421 patient specimens, genotype C was found in 419 (99.5%) and genotype B in 2 (0.5%). Among the genotype C strains, 417 strains were C2 subgenotype and 2 strains were mixed subgenotypes. However, C2 was evidently found even in the mixed sequences. Serotypes of 419 HBV with genotype C were classified as follows: adr, 385 (91.9%), adw, 22 (5.3%), ayr, 2 (0.4%) and mixed serotype, 10 (2.3%). Serotype of both HBV with genotype B was adw. Conclusions: It was found that HBV detected in Korean CHB patients under treatment almost all belong to the C2 (Ce) genotype.

Original languageKorean
Pages (from-to)53-58
Number of pages6
JournalKorean Journal of Laboratory Medicine
Volume29
Issue number1
DOIs
Publication statusPublished - 2009 Jun 22
Externally publishedYes

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Chronic Hepatitis B
Viruses
Hepatitis B virus
Genotype
Therapeutics
Antiviral Agents
Serogroup
Genes
Sequence Analysis
Hepatocellular Carcinoma

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Korean Source BKorean Source BKorean Source. / Cha, Choong Hwan; Sohn, Yong Hak; Ko, Sun-Young; Oh, Heung Bum.

In: Korean Journal of Laboratory Medicine, Vol. 29, No. 1, 22.06.2009, p. 53-58.

Research output: Contribution to journalArticle

Cha, Choong Hwan ; Sohn, Yong Hak ; Ko, Sun-Young ; Oh, Heung Bum. / Korean Source BKorean Source BKorean Source. In: Korean Journal of Laboratory Medicine. 2009 ; Vol. 29, No. 1. pp. 53-58.
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