Subject-specific estimation of missing cortical thickness maps in developing infant brains

Yu Meng; Gang Li; Yaozong Gao; John H. Gilmore; Weili Lin; Dinggang Shen

doi:10.1007/978-3-319-42016-5_8

Subject-specific estimation of missing cortical thickness maps in developing infant brains

Yu Meng, Gang Li, Yaozong Gao, John H. Gilmore, Weili Lin, Dinggang Shen

Department of Brain and Cognitive Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

To accurately chart the dynamic brain developmental trajectories in infants, many longitudinal neuroimaging studies prefer having a complete dataset. Unfortunately, missing data at certain time points are unavoidable in longitudinal datasets. To better use incomplete longitudinal data, we propose a novel method to estimate the subject-specific vertex-wise cortical thickness maps at missing time points, by using a customized regression forest, Dynamically-Assembled Regression Forest (DARF). DARF ensures spatial smoothness of the estimated cortical thickness maps and also the computational efficiency. The proposed method can fully exploit the available information from the subjects both with and without missing scans. Our method has been applied to estimate the missing cortical thickness maps in a longitudinal infant dataset, which includes 31 healthy subjects, with each having up to 5 scans. The experimental results indicate that our method can accurately estimate missing cortical thickness maps, with the average vertex-wise error less than 0.23 mm.

Original language	English
Title of host publication	Medical Computer Vision
Subtitle of host publication	Algorithms for Big Data - International Workshop, MCV 2015 and Held in Conjunction with MICCAI 2015, Revised Selected Papers
Editors	Michael Kelm, Henning Müller, Bjoern Menze, Shaoting Zhang, Dimitris Metaxas, Georg Langs, Albert Montillo, Weidong Cai
Publisher	Springer Verlag
Pages	83-92
Number of pages	10
ISBN (Print)	9783319420158
DOIs	https://doi.org/10.1007/978-3-319-42016-5_8
Publication status	Published - 2016
Event	International Workshop on Medical Image Computing for Computer Assisted Intervention, 2015 MICCAI - Germany, Germany Duration: 2015 Oct 9 → 2015 Oct 9

Publication series

Name	Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume	9601 LNCS
ISSN (Print)	0302-9743
ISSN (Electronic)	1611-3349

Other

Other	International Workshop on Medical Image Computing for Computer Assisted Intervention, 2015 MICCAI
Country	Germany
City	Germany
Period	15/10/9 → 15/10/9

Keywords

Infant brain development
Longitudinal cortical thickness
Missing data completion

ASJC Scopus subject areas

Theoretical Computer Science
Computer Science(all)

Access to Document

10.1007/978-3-319-42016-5_8

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Cite this

Meng, Y., Li, G., Gao, Y., Gilmore, J. H., Lin, W., & Shen, D. (2016). Subject-specific estimation of missing cortical thickness maps in developing infant brains. In M. Kelm, H. Müller, B. Menze, S. Zhang, D. Metaxas, G. Langs, A. Montillo, & W. Cai (Eds.), Medical Computer Vision: Algorithms for Big Data - International Workshop, MCV 2015 and Held in Conjunction with MICCAI 2015, Revised Selected Papers (pp. 83-92). (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 9601 LNCS). Springer Verlag. https://doi.org/10.1007/978-3-319-42016-5_8

Subject-specific estimation of missing cortical thickness maps in developing infant brains. / Meng, Yu; Li, Gang; Gao, Yaozong; Gilmore, John H.; Lin, Weili; Shen, Dinggang.

Medical Computer Vision: Algorithms for Big Data - International Workshop, MCV 2015 and Held in Conjunction with MICCAI 2015, Revised Selected Papers. ed. / Michael Kelm; Henning Müller; Bjoern Menze; Shaoting Zhang; Dimitris Metaxas; Georg Langs; Albert Montillo; Weidong Cai. Springer Verlag, 2016. p. 83-92 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 9601 LNCS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Meng, Y, Li, G, Gao, Y, Gilmore, JH, Lin, W & Shen, D 2016, Subject-specific estimation of missing cortical thickness maps in developing infant brains. in M Kelm, H Müller, B Menze, S Zhang, D Metaxas, G Langs, A Montillo & W Cai (eds), Medical Computer Vision: Algorithms for Big Data - International Workshop, MCV 2015 and Held in Conjunction with MICCAI 2015, Revised Selected Papers. Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), vol. 9601 LNCS, Springer Verlag, pp. 83-92, International Workshop on Medical Image Computing for Computer Assisted Intervention, 2015 MICCAI, Germany, Germany, 15/10/9. https://doi.org/10.1007/978-3-319-42016-5_8

Meng Y, Li G, Gao Y, Gilmore JH, Lin W, Shen D. Subject-specific estimation of missing cortical thickness maps in developing infant brains. In Kelm M, Müller H, Menze B, Zhang S, Metaxas D, Langs G, Montillo A, Cai W, editors, Medical Computer Vision: Algorithms for Big Data - International Workshop, MCV 2015 and Held in Conjunction with MICCAI 2015, Revised Selected Papers. Springer Verlag. 2016. p. 83-92. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)). https://doi.org/10.1007/978-3-319-42016-5_8

Meng, Yu ; Li, Gang ; Gao, Yaozong ; Gilmore, John H. ; Lin, Weili ; Shen, Dinggang. / Subject-specific estimation of missing cortical thickness maps in developing infant brains. Medical Computer Vision: Algorithms for Big Data - International Workshop, MCV 2015 and Held in Conjunction with MICCAI 2015, Revised Selected Papers. editor / Michael Kelm ; Henning Müller ; Bjoern Menze ; Shaoting Zhang ; Dimitris Metaxas ; Georg Langs ; Albert Montillo ; Weidong Cai. Springer Verlag, 2016. pp. 83-92 (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)).

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AB - To accurately chart the dynamic brain developmental trajectories in infants, many longitudinal neuroimaging studies prefer having a complete dataset. Unfortunately, missing data at certain time points are unavoidable in longitudinal datasets. To better use incomplete longitudinal data, we propose a novel method to estimate the subject-specific vertex-wise cortical thickness maps at missing time points, by using a customized regression forest, Dynamically-Assembled Regression Forest (DARF). DARF ensures spatial smoothness of the estimated cortical thickness maps and also the computational efficiency. The proposed method can fully exploit the available information from the subjects both with and without missing scans. Our method has been applied to estimate the missing cortical thickness maps in a longitudinal infant dataset, which includes 31 healthy subjects, with each having up to 5 scans. The experimental results indicate that our method can accurately estimate missing cortical thickness maps, with the average vertex-wise error less than 0.23 mm.

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