Abstract
In chemical synthesis, rapid intramolecular rearrangements often foil attempts at site-selective bimolecular functionalization.We developed a microfluidic technique that outpaces the very rapid anionic Fries rearrangement to chemoselectively functionalize iodophenyl carbamates at the ortho position. Central to the technique is a chip microreactor of our design, which can deliver a reaction time in the submillisecond range even at cryogenic temperatures.The microreactorwas applied to the synthesis of afesal, a bioactive molecule exhibiting anthelmintic activity, to demonstrate its potential for practical synthesis and production.
Original language | English |
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Pages (from-to) | 691-694 |
Number of pages | 4 |
Journal | Science |
Volume | 352 |
Issue number | 6286 |
DOIs | |
Publication status | Published - 2016 May 6 |
Externally published | Yes |
ASJC Scopus subject areas
- General