@article{8064f4167cda4800a7d2206ec73a4e50,
title = "Submillisecond organic synthesis: Outpacing Fries rearrangement through microfluidic rapid mixing",
abstract = "In chemical synthesis, rapid intramolecular rearrangements often foil attempts at site-selective bimolecular functionalization.We developed a microfluidic technique that outpaces the very rapid anionic Fries rearrangement to chemoselectively functionalize iodophenyl carbamates at the ortho position. Central to the technique is a chip microreactor of our design, which can deliver a reaction time in the submillisecond range even at cryogenic temperatures.The microreactorwas applied to the synthesis of afesal, a bioactive molecule exhibiting anthelmintic activity, to demonstrate its potential for practical synthesis and production.",
author = "Heejin Kim and Min, {Kyoung Ik} and Keita Inoue and Im, {Do Jin} and Kim, {Dong Pyo} and Yoshida, {Jun Ichi}",
note = "Funding Information: Supported by National Research Foundation of Korea grants 2008-0061983, NRF-2015R1D1A3A01019112, and NRF-2014M1A8A1074940 and by Japan Society for the Promotion of Science Grant-in-Aid for Scientific Research (S) 26220804. Author contributions: H.K. and K.-I.M. conceived the concept at POSTECH; K.-I.M. fabricated the device; H.K. conducted synthetic experiments at POSETCH and Kyoto University with K.I.; D.J.I. conducted CFD simulation and analysis with K.-I.M.; and D.-P.K. and J.Y. directed the project. Copyright: Copyright 2016 Elsevier B.V., All rights reserved.",
year = "2016",
month = may,
day = "6",
doi = "10.1126/science.aaf1389",
language = "English",
volume = "352",
pages = "691--694",
journal = "Science",
issn = "0036-8075",
publisher = "American Association for the Advancement of Science",
number = "6286",
}