Suboptimal effectiveness of the 2011-2012 seasonal influenza vaccine in adult Korean populations

Wonseok Choi, Ji Yun Noh, Ji Hyeon Baek, Yu Bin Seo, Jacob Lee, Joon-Young Song, Dae Won Park, Jin Soo Lee, Hee-Jin Cheong, Woo Joo Kim

Research output: Contribution to journalArticle

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Abstract

Background: The effectiveness of the 2011-2012 seasonal influenza vaccine was evaluated in adult Korean populations with regard to how well it could prevent laboratory-confirmed influenza and influenza-related complications. Materials and Methods: A retrospective case-control and retrospective cohort study was conducted among patients who visited four selected hospitals from September 2011 to May 2012. The analysis included 1,130 laboratory-confirmed influenza patients. For each influenza case, one control patient was chosen at a ratio of 1:1. A control was defined as an age group-matched patient who visited the same hospital with influenza-like illness within 48 hours of symptom onset but for whom laboratory tests were negative for influenza. Age group and visit date were matched between the cases and controls. Vaccine effectiveness (VE) was defined as [100 × (1-odds ratio for influenza in vaccinated versus non-vaccinated persons)]. The patients with laboratory-confirmed influenza were followed for at least one month through reviewing the medical records and conducting a telephone interview. Results: The VE of the 2011-2012 seasonal influenza vaccine was 3.8% [95% confidence interval (CI), -16.5% to 20.6%] for preventing laboratory-confirmed influenza, -16.1% (95% CI, -48.3 to 9.1) for influenza A and 26.2%(95% CI, -2.6 to 46.2) for influenza B. The age-specific adjusted VE was 0.3% (95% CI, -29.4 to 23.1) among participants aged 19 to 49 years, 11.9% (95% CI, -34.3 to 42.2) among those aged 50 to 64 years and -3.9% (-60.1 to 32.5) among those aged ≥65 years. The adjusted VE for preventing any influenza-related complications was -10.7% (95% CI, -41.1% to 42.2%). Conclusions: The 2011-2012 seasonal influenza vaccine was not effective in preventing laboratory-confirmed influenza or influenza-related complications in adult Korean populations.

Original languageEnglish
Article numbere0098716
JournalPLoS One
Volume10
Issue number3
DOIs
Publication statusPublished - 2015 Mar 27

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Influenza Vaccines
influenza
Human Influenza
vaccines
Vaccines
Population
confidence interval
Confidence Intervals
Telephone
Age Groups
Medical Records
cohort studies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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Suboptimal effectiveness of the 2011-2012 seasonal influenza vaccine in adult Korean populations. / Choi, Wonseok; Noh, Ji Yun; Baek, Ji Hyeon; Seo, Yu Bin; Lee, Jacob; Song, Joon-Young; Park, Dae Won; Lee, Jin Soo; Cheong, Hee-Jin; Kim, Woo Joo.

In: PLoS One, Vol. 10, No. 3, e0098716, 27.03.2015.

Research output: Contribution to journalArticle

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title = "Suboptimal effectiveness of the 2011-2012 seasonal influenza vaccine in adult Korean populations",
abstract = "Background: The effectiveness of the 2011-2012 seasonal influenza vaccine was evaluated in adult Korean populations with regard to how well it could prevent laboratory-confirmed influenza and influenza-related complications. Materials and Methods: A retrospective case-control and retrospective cohort study was conducted among patients who visited four selected hospitals from September 2011 to May 2012. The analysis included 1,130 laboratory-confirmed influenza patients. For each influenza case, one control patient was chosen at a ratio of 1:1. A control was defined as an age group-matched patient who visited the same hospital with influenza-like illness within 48 hours of symptom onset but for whom laboratory tests were negative for influenza. Age group and visit date were matched between the cases and controls. Vaccine effectiveness (VE) was defined as [100 × (1-odds ratio for influenza in vaccinated versus non-vaccinated persons)]. The patients with laboratory-confirmed influenza were followed for at least one month through reviewing the medical records and conducting a telephone interview. Results: The VE of the 2011-2012 seasonal influenza vaccine was 3.8{\%} [95{\%} confidence interval (CI), -16.5{\%} to 20.6{\%}] for preventing laboratory-confirmed influenza, -16.1{\%} (95{\%} CI, -48.3 to 9.1) for influenza A and 26.2{\%}(95{\%} CI, -2.6 to 46.2) for influenza B. The age-specific adjusted VE was 0.3{\%} (95{\%} CI, -29.4 to 23.1) among participants aged 19 to 49 years, 11.9{\%} (95{\%} CI, -34.3 to 42.2) among those aged 50 to 64 years and -3.9{\%} (-60.1 to 32.5) among those aged ≥65 years. The adjusted VE for preventing any influenza-related complications was -10.7{\%} (95{\%} CI, -41.1{\%} to 42.2{\%}). Conclusions: The 2011-2012 seasonal influenza vaccine was not effective in preventing laboratory-confirmed influenza or influenza-related complications in adult Korean populations.",
author = "Wonseok Choi and Noh, {Ji Yun} and Baek, {Ji Hyeon} and Seo, {Yu Bin} and Jacob Lee and Joon-Young Song and Park, {Dae Won} and Lee, {Jin Soo} and Hee-Jin Cheong and Kim, {Woo Joo}",
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AU - Choi, Wonseok

AU - Noh, Ji Yun

AU - Baek, Ji Hyeon

AU - Seo, Yu Bin

AU - Lee, Jacob

AU - Song, Joon-Young

AU - Park, Dae Won

AU - Lee, Jin Soo

AU - Cheong, Hee-Jin

AU - Kim, Woo Joo

PY - 2015/3/27

Y1 - 2015/3/27

N2 - Background: The effectiveness of the 2011-2012 seasonal influenza vaccine was evaluated in adult Korean populations with regard to how well it could prevent laboratory-confirmed influenza and influenza-related complications. Materials and Methods: A retrospective case-control and retrospective cohort study was conducted among patients who visited four selected hospitals from September 2011 to May 2012. The analysis included 1,130 laboratory-confirmed influenza patients. For each influenza case, one control patient was chosen at a ratio of 1:1. A control was defined as an age group-matched patient who visited the same hospital with influenza-like illness within 48 hours of symptom onset but for whom laboratory tests were negative for influenza. Age group and visit date were matched between the cases and controls. Vaccine effectiveness (VE) was defined as [100 × (1-odds ratio for influenza in vaccinated versus non-vaccinated persons)]. The patients with laboratory-confirmed influenza were followed for at least one month through reviewing the medical records and conducting a telephone interview. Results: The VE of the 2011-2012 seasonal influenza vaccine was 3.8% [95% confidence interval (CI), -16.5% to 20.6%] for preventing laboratory-confirmed influenza, -16.1% (95% CI, -48.3 to 9.1) for influenza A and 26.2%(95% CI, -2.6 to 46.2) for influenza B. The age-specific adjusted VE was 0.3% (95% CI, -29.4 to 23.1) among participants aged 19 to 49 years, 11.9% (95% CI, -34.3 to 42.2) among those aged 50 to 64 years and -3.9% (-60.1 to 32.5) among those aged ≥65 years. The adjusted VE for preventing any influenza-related complications was -10.7% (95% CI, -41.1% to 42.2%). Conclusions: The 2011-2012 seasonal influenza vaccine was not effective in preventing laboratory-confirmed influenza or influenza-related complications in adult Korean populations.

AB - Background: The effectiveness of the 2011-2012 seasonal influenza vaccine was evaluated in adult Korean populations with regard to how well it could prevent laboratory-confirmed influenza and influenza-related complications. Materials and Methods: A retrospective case-control and retrospective cohort study was conducted among patients who visited four selected hospitals from September 2011 to May 2012. The analysis included 1,130 laboratory-confirmed influenza patients. For each influenza case, one control patient was chosen at a ratio of 1:1. A control was defined as an age group-matched patient who visited the same hospital with influenza-like illness within 48 hours of symptom onset but for whom laboratory tests were negative for influenza. Age group and visit date were matched between the cases and controls. Vaccine effectiveness (VE) was defined as [100 × (1-odds ratio for influenza in vaccinated versus non-vaccinated persons)]. The patients with laboratory-confirmed influenza were followed for at least one month through reviewing the medical records and conducting a telephone interview. Results: The VE of the 2011-2012 seasonal influenza vaccine was 3.8% [95% confidence interval (CI), -16.5% to 20.6%] for preventing laboratory-confirmed influenza, -16.1% (95% CI, -48.3 to 9.1) for influenza A and 26.2%(95% CI, -2.6 to 46.2) for influenza B. The age-specific adjusted VE was 0.3% (95% CI, -29.4 to 23.1) among participants aged 19 to 49 years, 11.9% (95% CI, -34.3 to 42.2) among those aged 50 to 64 years and -3.9% (-60.1 to 32.5) among those aged ≥65 years. The adjusted VE for preventing any influenza-related complications was -10.7% (95% CI, -41.1% to 42.2%). Conclusions: The 2011-2012 seasonal influenza vaccine was not effective in preventing laboratory-confirmed influenza or influenza-related complications in adult Korean populations.

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