Substance P and neuropeptide y as potential biomarkers for diagnosis of acute myocardial infarction in korean patients

Hyojeong Han; Hong Seog Seo; Byung Hwa Jung; Kyoungja Woo; Young Sook Yoo; Min Jung Kang

doi:10.5012/bkcs.2014.35.1.158

Substance P and neuropeptide y as potential biomarkers for diagnosis of acute myocardial infarction in korean patients

Hyojeong Han, Hong Seog Seo, Byung Hwa Jung, Kyoungja Woo, Young Sook Yoo, Min Jung Kang

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Substance P and neuropeptide Y were discovered as early diagnostic biomarkers of acute myocardial infarction in Korean patients and confirmed using enzyme-linked immunosorbent assay (ELISA). We screened 12 peptides from the sera of Korean acute myocardial infarction (AMI) patients and detected 3 peptides (neuropeptide Y, substance P, and N-terminal pro-B-type natriuretic peptide) to be elevated from patients sera by liquid chromatography mass/mass spectrometry. The elevated concentration of 3 peptides was confirmed by ELISA. The screening results revealed the substance P, neuropeptide Y, and pro-B-type natriuretic peptide (47-76) concentrations were higher in patients sera than in healthy controls. The sensitivity and specificity of substance P for AMI diagnostic marker were 80% and 83%, respectively, and those of neuropeptide Y were 87% and 90%, respectively compared to healthy controls. These results suggest that substance P and neuropeptide Y could be used as early diagnostic biomarkers in patients with AMI.

Original language	English
Pages (from-to)	158-164
Number of pages	7
Journal	Bulletin of the Korean Chemical Society
Volume	35
Issue number	1
DOIs	https://doi.org/10.5012/bkcs.2014.35.1.158
Publication status	Published - 2014 Jan 20

Keywords

Acute myocardial infarction
Biomarker
LC-MS
Neuropeptide Y
Substance P

ASJC Scopus subject areas

Chemistry(all)

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10.5012/bkcs.2014.35.1.158

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title = "Substance P and neuropeptide y as potential biomarkers for diagnosis of acute myocardial infarction in korean patients",

abstract = "Substance P and neuropeptide Y were discovered as early diagnostic biomarkers of acute myocardial infarction in Korean patients and confirmed using enzyme-linked immunosorbent assay (ELISA). We screened 12 peptides from the sera of Korean acute myocardial infarction (AMI) patients and detected 3 peptides (neuropeptide Y, substance P, and N-terminal pro-B-type natriuretic peptide) to be elevated from patients sera by liquid chromatography mass/mass spectrometry. The elevated concentration of 3 peptides was confirmed by ELISA. The screening results revealed the substance P, neuropeptide Y, and pro-B-type natriuretic peptide (47-76) concentrations were higher in patients sera than in healthy controls. The sensitivity and specificity of substance P for AMI diagnostic marker were 80% and 83%, respectively, and those of neuropeptide Y were 87% and 90%, respectively compared to healthy controls. These results suggest that substance P and neuropeptide Y could be used as early diagnostic biomarkers in patients with AMI.",

keywords = "Acute myocardial infarction, Biomarker, LC-MS, Neuropeptide Y, Substance P",

author = "Hyojeong Han and Seo, {Hong Seog} and Jung, {Byung Hwa} and Kyoungja Woo and Yoo, {Young Sook} and Kang, {Min Jung}",

year = "2014",

month = jan,

day = "20",

doi = "10.5012/bkcs.2014.35.1.158",

language = "English",

volume = "35",

pages = "158--164",

journal = "Bulletin of the Korean Chemical Society",

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T1 - Substance P and neuropeptide y as potential biomarkers for diagnosis of acute myocardial infarction in korean patients

AU - Han, Hyojeong

AU - Seo, Hong Seog

AU - Jung, Byung Hwa

AU - Woo, Kyoungja

AU - Yoo, Young Sook

AU - Kang, Min Jung

PY - 2014/1/20

Y1 - 2014/1/20

N2 - Substance P and neuropeptide Y were discovered as early diagnostic biomarkers of acute myocardial infarction in Korean patients and confirmed using enzyme-linked immunosorbent assay (ELISA). We screened 12 peptides from the sera of Korean acute myocardial infarction (AMI) patients and detected 3 peptides (neuropeptide Y, substance P, and N-terminal pro-B-type natriuretic peptide) to be elevated from patients sera by liquid chromatography mass/mass spectrometry. The elevated concentration of 3 peptides was confirmed by ELISA. The screening results revealed the substance P, neuropeptide Y, and pro-B-type natriuretic peptide (47-76) concentrations were higher in patients sera than in healthy controls. The sensitivity and specificity of substance P for AMI diagnostic marker were 80% and 83%, respectively, and those of neuropeptide Y were 87% and 90%, respectively compared to healthy controls. These results suggest that substance P and neuropeptide Y could be used as early diagnostic biomarkers in patients with AMI.

AB - Substance P and neuropeptide Y were discovered as early diagnostic biomarkers of acute myocardial infarction in Korean patients and confirmed using enzyme-linked immunosorbent assay (ELISA). We screened 12 peptides from the sera of Korean acute myocardial infarction (AMI) patients and detected 3 peptides (neuropeptide Y, substance P, and N-terminal pro-B-type natriuretic peptide) to be elevated from patients sera by liquid chromatography mass/mass spectrometry. The elevated concentration of 3 peptides was confirmed by ELISA. The screening results revealed the substance P, neuropeptide Y, and pro-B-type natriuretic peptide (47-76) concentrations were higher in patients sera than in healthy controls. The sensitivity and specificity of substance P for AMI diagnostic marker were 80% and 83%, respectively, and those of neuropeptide Y were 87% and 90%, respectively compared to healthy controls. These results suggest that substance P and neuropeptide Y could be used as early diagnostic biomarkers in patients with AMI.

KW - Acute myocardial infarction

KW - Biomarker

KW - LC-MS

KW - Neuropeptide Y

KW - Substance P

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JO - Bulletin of the Korean Chemical Society

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Substance P and neuropeptide y as potential biomarkers for diagnosis of acute myocardial infarction in korean patients

Abstract

Keywords

ASJC Scopus subject areas

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