Substance P and neuropeptide y as potential biomarkers for diagnosis of acute myocardial infarction in korean patients

Hyojeong Han, Hong Seog Seo, Byung Hwa Jung, Kyoungja Woo, Young Sook Yoo, Min Jung Kang

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2 Citations (Scopus)

Abstract

Substance P and neuropeptide Y were discovered as early diagnostic biomarkers of acute myocardial infarction in Korean patients and confirmed using enzyme-linked immunosorbent assay (ELISA). We screened 12 peptides from the sera of Korean acute myocardial infarction (AMI) patients and detected 3 peptides (neuropeptide Y, substance P, and N-terminal pro-B-type natriuretic peptide) to be elevated from patients sera by liquid chromatography mass/mass spectrometry. The elevated concentration of 3 peptides was confirmed by ELISA. The screening results revealed the substance P, neuropeptide Y, and pro-B-type natriuretic peptide (47-76) concentrations were higher in patients sera than in healthy controls. The sensitivity and specificity of substance P for AMI diagnostic marker were 80% and 83%, respectively, and those of neuropeptide Y were 87% and 90%, respectively compared to healthy controls. These results suggest that substance P and neuropeptide Y could be used as early diagnostic biomarkers in patients with AMI.

Original languageEnglish
Pages (from-to)158-164
Number of pages7
JournalBulletin of the Korean Chemical Society
Volume35
Issue number1
DOIs
Publication statusPublished - 2014 Jan 20

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Keywords

  • Acute myocardial infarction
  • Biomarker
  • LC-MS
  • Neuropeptide Y
  • Substance P

ASJC Scopus subject areas

  • Chemistry(all)

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