Abstract
Background: Unlike classic asthma, cough-variant asthma does not show any evidence of airway obstruction. The main symptom is a dry cough with little known pathophysiology. Hypersensitivity of the cough receptors in cough-variant asthma and an increase in the sensory nerve density of the airway epithelium in persistent dry cough patients have been reported. Therefore, it is possible that there is a higher sensory nerve density in cough-variant asthma patients than in classic asthma patients. Objectives: This study was undertaken to compare the substance P (SP)-immunoreactive nerve density in mucosal biopsies of cough-variant asthma patients, classic asthma patients, and in control subjects. Methods: Bronchoscopic biopsies were performed in 6 cough-variant asthma patients, 14 classic asthma patients, and 5 normal controls. The tissues obtained were stained immunohistochemically. The SP-immunoreactive nerve density was measured in the bronchial epithelium using a light microscope at 400x magnification. Results: SP-immunoreactive nerve density for the cough-variant asthma group was significantly higher than that of the classic asthma group (p = 0.001), and of the normal control group (p = 0.006). Conclusions: It is possible that a sensory nerve abnormality within the airway may be related to hypersensitivity of the cough receptor, and that this may be one of the pathophysiologies of cough-variant asthma.
| Original language | English |
|---|---|
| Pages (from-to) | 49-53 |
| Number of pages | 5 |
| Journal | Respiration |
| Volume | 70 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2003 Feb 27 |
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Keywords
- Classic asthma
- Cough-variant asthma
- Substance P-immunoreactive nerves
ASJC Scopus subject areas
- Pulmonary and Respiratory Medicine
- Physiology
Cite this
Substance P-immunoreactive nerves in endobronchial biopsies in cough-variant asthma and classic asthma. / Lee, Sang Yeub; Kim, Min Kyung; Shin, Chol; Shim, Jae Jeong; Kim, Han Kyeom; Kang, Kyung Ho; Yoo, Se Hwa; In, Kwang Ho.
In: Respiration, Vol. 70, No. 1, 27.02.2003, p. 49-53.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Substance P-immunoreactive nerves in endobronchial biopsies in cough-variant asthma and classic asthma
AU - Lee, Sang Yeub
AU - Kim, Min Kyung
AU - Shin, Chol
AU - Shim, Jae Jeong
AU - Kim, Han Kyeom
AU - Kang, Kyung Ho
AU - Yoo, Se Hwa
AU - In, Kwang Ho
PY - 2003/2/27
Y1 - 2003/2/27
N2 - Background: Unlike classic asthma, cough-variant asthma does not show any evidence of airway obstruction. The main symptom is a dry cough with little known pathophysiology. Hypersensitivity of the cough receptors in cough-variant asthma and an increase in the sensory nerve density of the airway epithelium in persistent dry cough patients have been reported. Therefore, it is possible that there is a higher sensory nerve density in cough-variant asthma patients than in classic asthma patients. Objectives: This study was undertaken to compare the substance P (SP)-immunoreactive nerve density in mucosal biopsies of cough-variant asthma patients, classic asthma patients, and in control subjects. Methods: Bronchoscopic biopsies were performed in 6 cough-variant asthma patients, 14 classic asthma patients, and 5 normal controls. The tissues obtained were stained immunohistochemically. The SP-immunoreactive nerve density was measured in the bronchial epithelium using a light microscope at 400x magnification. Results: SP-immunoreactive nerve density for the cough-variant asthma group was significantly higher than that of the classic asthma group (p = 0.001), and of the normal control group (p = 0.006). Conclusions: It is possible that a sensory nerve abnormality within the airway may be related to hypersensitivity of the cough receptor, and that this may be one of the pathophysiologies of cough-variant asthma.
AB - Background: Unlike classic asthma, cough-variant asthma does not show any evidence of airway obstruction. The main symptom is a dry cough with little known pathophysiology. Hypersensitivity of the cough receptors in cough-variant asthma and an increase in the sensory nerve density of the airway epithelium in persistent dry cough patients have been reported. Therefore, it is possible that there is a higher sensory nerve density in cough-variant asthma patients than in classic asthma patients. Objectives: This study was undertaken to compare the substance P (SP)-immunoreactive nerve density in mucosal biopsies of cough-variant asthma patients, classic asthma patients, and in control subjects. Methods: Bronchoscopic biopsies were performed in 6 cough-variant asthma patients, 14 classic asthma patients, and 5 normal controls. The tissues obtained were stained immunohistochemically. The SP-immunoreactive nerve density was measured in the bronchial epithelium using a light microscope at 400x magnification. Results: SP-immunoreactive nerve density for the cough-variant asthma group was significantly higher than that of the classic asthma group (p = 0.001), and of the normal control group (p = 0.006). Conclusions: It is possible that a sensory nerve abnormality within the airway may be related to hypersensitivity of the cough receptor, and that this may be one of the pathophysiologies of cough-variant asthma.
KW - Classic asthma
KW - Cough-variant asthma
KW - Substance P-immunoreactive nerves
UR - http://www.scopus.com/inward/record.url?scp=12244294466&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=12244294466&partnerID=8YFLogxK
U2 - 10.1159/000068413
DO - 10.1159/000068413
M3 - Article
C2 - 12584391
AN - SCOPUS:12244294466
VL - 70
SP - 49
EP - 53
JO - Respiration; international review of thoracic diseases
JF - Respiration; international review of thoracic diseases
SN - 0025-7931
IS - 1
ER -