Successful salvage treatment of steroid-refractory bronchiolar COP with low-dose macrolides

Won Jin Chang, Eun Joo Lee, Sang Yeub Lee, Kwang Ho In, Chul Hwan Kim, Han Kyeom Kim, Sanghoon Park

    Research output: Contribution to journalArticlepeer-review

    12 Citations (Scopus)

    Abstract

    Cryptogenic organizing pneumonia (COP) is an idiopathic interstitial pneumonia characterized by fibroblastic tissues that occupy the lumina of alveoli and alveolar ducts or respiratory bronchioles. Although adequate doses and durations of glucocorticoids can improve its condition, COP is sometimes resistant to glucocorticoid therapy and is often lethal.Herein, a very rare case of 'bronchiolar COP' that was confined to the respiratory bronchioles is reported. This case indicates that macrolides may act as anti-inflammatory agents in patients with COP. Timely and precise pathological diagnosis may corroborate clinician diagnoses and eventually improve chances to overcome the disease.

    Original languageEnglish
    Pages (from-to)144-148
    Number of pages5
    JournalPathology International
    Volume62
    Issue number2
    DOIs
    Publication statusPublished - 2012 Feb

    Keywords

    • Cryptogenic organizing pneumonia
    • Interstitial lung diseases
    • Macrolides
    • Respiratory bronchiole

    ASJC Scopus subject areas

    • Pathology and Forensic Medicine

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