Successful treatment of disseminated interdigitating dendritic cell sarcoma with adriamycin, bleomycin, vinblastine, and dacarbazine chemotherapy

Suk young Lee, Se Ryeon Lee, Won Jin Chang, Hye Sook Kim, Byung Soo Kim, In Sun Kim

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Interdigitating dendritic cell sarcoma (IDCS) is a very rare and aggressive neoplasm that arises from antigen presenting cells. IDCS usually involves lymph nodes; however, extra- nodal involvement has also been reported. Because a consistent standard therapy for IDCS has not been established to date, we report a case of the successful treatment of disseminated IDCS using ABVD chemotherapy (doxorubicin, bleomycin, vinblastine, and dacarbazine). A 64-year-old man was diagnosed with IDCS on the basis of immunohistochemical findings of a biopsy specimen of the inferior nasal concha. Immunohistochemical staining showed a positive reaction for CD68, leukocyte common antigen, and S-100 protein, but a negative reaction for CD34, CD1a, and CD21. Imaging studies showed cervical and axillary lymphadenopathies, subcutaneous nodules, and a soft tissue lesion in the nasal cavity. Treatment with the ABVD regimen resulted in complete remission after 8 cycles of chemotherapy.

Original languageEnglish
Pages (from-to)150-153
Number of pages4
JournalKorean Journal of Hematology
Volume47
Issue number2
DOIs
Publication statusPublished - 2012 Jun

Keywords

  • ABVD chemotherapy
  • Complete remission
  • IDCS

ASJC Scopus subject areas

  • Hematology

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