Successful treatment of nicolau syndrome with platelet rich plasma

Dai Hyun Kim, Ga Na Oh, Jong Yeob Kim, Jae Eun Choi, Hyo Hyun Ahn, Young Chul Kye, Soo Hong Seo

Research output: Contribution to journalArticlepeer-review


Platelet rich plasma (PRP) therapy has been growing in popularity as a viable treatment alternative for a number of clinical applications and has a potential benefit for use in wound healing. The objective of the present study was to verify the effectiveness of PRP in the management of the refractory cutaneous ulcer associated with Nicolau syndrome. A 73-year-old woman with a diclofenac sodium intramuscular injection history in a local clinic presented with a severely painful acute necrotic ulcer on the right buttock. The ulcerative wound showed no improvement despite having conventional treatment for 1 month. After 3 weeks of the PRP treatment, the wound evolved favorably, with the alleviation of severe pain. It showed a size reduction of more than 80% after 4 months of regular follow up. The result demonstrated that PRP treatment could be an appropriate option for an extensive refractory ulceration associated with Nicolau syndrom.

Original languageEnglish
Pages (from-to)69-71
Number of pages3
JournalKorean Journal of Dermatology
Issue number1
Publication statusPublished - 2013 Jan
Externally publishedYes


  • Nicolau syndrome
  • Platelet rich plasma
  • Refractory ulceration

ASJC Scopus subject areas

  • Dermatology


Dive into the research topics of 'Successful treatment of nicolau syndrome with platelet rich plasma'. Together they form a unique fingerprint.

Cite this