SU‐FF‐T‐398: Study of Inhomogeneous Dose Distribution in a Cell Box Due to the X‐Ray Scattering Effect

Myonggeun Yoon, J. Shin, D. Shin, S. Lee, S. Park, D. Lee, J. Kim, H. Pyo, K. Shin, K. Cho

Research output: Contribution to journalArticle

Abstract

Purpose: The ratio of hypoxic to aerated doses needed to achieve the same biological effects, called the oxygen enhancement ratio (OER), is very important factor in radiotherapy since none produces such a dramatic effect and no other agent has such obvious practical implication. Although it is usually assumed that the dose distribution in a cell box is uniform, the absorbed dose to the tumor cells could be very different according to the locations of the cells within a cell box, which affects the cell survival curves. We have studied the inhomogeneous dose distribution in a cell box due to the scattering of x‐rays with the cover and side‐walls of cell box. Method and Materials: Three different sizes of cubical cell boxes, whose side lengths are 10, 15, 20 cm, were designed and irradiated by 6 and 15 MV x‐rays using Varian 2100CD linear accelerator. Results: The differences of the absorbed doses at the center between 10×10×10 cm3 box and 20×20×20 cm3 box were less than 2 % for 6 MV and 15 MV x‐ray irradiation, which indicates that the scattering effect depending on the size of cell box is not significant for the absolute absorbed dose at the center of box. However, the relative dose distribution within the cell box shows very different behavior revealing distinct heterogeneous dose distribution in a cell box. For example, the percentage showing more than 10 % dose difference within the cell box was ∼ 40 % for 20×20×20 cm3 box with 15 MV x‐ray irradiation. Conclusion: While the dose inhomogeneity for 15 MV x‐ray irradiation increases as the size of cell box increases, the dose inhomogeneity for 6 MV x‐ray doesn't show any size dependency. Our experimental evidence suggests that the dose inhomogeneity within the cell box is not negligible.

Original languageEnglish
Pages (from-to)2137
Number of pages1
JournalMedical Physics
Volume33
Issue number6
DOIs
Publication statusPublished - 2006
Externally publishedYes

Fingerprint

X-Rays
Cell Size
Particle Accelerators
Cell Survival
Radiotherapy
Oxygen
Neoplasms

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

SU‐FF‐T‐398 : Study of Inhomogeneous Dose Distribution in a Cell Box Due to the X‐Ray Scattering Effect. / Yoon, Myonggeun; Shin, J.; Shin, D.; Lee, S.; Park, S.; Lee, D.; Kim, J.; Pyo, H.; Shin, K.; Cho, K.

In: Medical Physics, Vol. 33, No. 6, 2006, p. 2137.

Research output: Contribution to journalArticle

Yoon, M, Shin, J, Shin, D, Lee, S, Park, S, Lee, D, Kim, J, Pyo, H, Shin, K & Cho, K 2006, 'SU‐FF‐T‐398: Study of Inhomogeneous Dose Distribution in a Cell Box Due to the X‐Ray Scattering Effect', Medical Physics, vol. 33, no. 6, pp. 2137. https://doi.org/10.1118/1.2241317
Yoon, Myonggeun ; Shin, J. ; Shin, D. ; Lee, S. ; Park, S. ; Lee, D. ; Kim, J. ; Pyo, H. ; Shin, K. ; Cho, K. / SU‐FF‐T‐398 : Study of Inhomogeneous Dose Distribution in a Cell Box Due to the X‐Ray Scattering Effect. In: Medical Physics. 2006 ; Vol. 33, No. 6. pp. 2137.
@article{43e19523be794c4ba5fba80edff02433,
title = "SU‐FF‐T‐398: Study of Inhomogeneous Dose Distribution in a Cell Box Due to the X‐Ray Scattering Effect",
abstract = "Purpose: The ratio of hypoxic to aerated doses needed to achieve the same biological effects, called the oxygen enhancement ratio (OER), is very important factor in radiotherapy since none produces such a dramatic effect and no other agent has such obvious practical implication. Although it is usually assumed that the dose distribution in a cell box is uniform, the absorbed dose to the tumor cells could be very different according to the locations of the cells within a cell box, which affects the cell survival curves. We have studied the inhomogeneous dose distribution in a cell box due to the scattering of x‐rays with the cover and side‐walls of cell box. Method and Materials: Three different sizes of cubical cell boxes, whose side lengths are 10, 15, 20 cm, were designed and irradiated by 6 and 15 MV x‐rays using Varian 2100CD linear accelerator. Results: The differences of the absorbed doses at the center between 10×10×10 cm3 box and 20×20×20 cm3 box were less than 2 {\%} for 6 MV and 15 MV x‐ray irradiation, which indicates that the scattering effect depending on the size of cell box is not significant for the absolute absorbed dose at the center of box. However, the relative dose distribution within the cell box shows very different behavior revealing distinct heterogeneous dose distribution in a cell box. For example, the percentage showing more than 10 {\%} dose difference within the cell box was ∼ 40 {\%} for 20×20×20 cm3 box with 15 MV x‐ray irradiation. Conclusion: While the dose inhomogeneity for 15 MV x‐ray irradiation increases as the size of cell box increases, the dose inhomogeneity for 6 MV x‐ray doesn't show any size dependency. Our experimental evidence suggests that the dose inhomogeneity within the cell box is not negligible.",
author = "Myonggeun Yoon and J. Shin and D. Shin and S. Lee and S. Park and D. Lee and J. Kim and H. Pyo and K. Shin and K. Cho",
year = "2006",
doi = "10.1118/1.2241317",
language = "English",
volume = "33",
pages = "2137",
journal = "Medical Physics",
issn = "0094-2405",
publisher = "AAPM - American Association of Physicists in Medicine",
number = "6",

}

TY - JOUR

T1 - SU‐FF‐T‐398

T2 - Study of Inhomogeneous Dose Distribution in a Cell Box Due to the X‐Ray Scattering Effect

AU - Yoon, Myonggeun

AU - Shin, J.

AU - Shin, D.

AU - Lee, S.

AU - Park, S.

AU - Lee, D.

AU - Kim, J.

AU - Pyo, H.

AU - Shin, K.

AU - Cho, K.

PY - 2006

Y1 - 2006

N2 - Purpose: The ratio of hypoxic to aerated doses needed to achieve the same biological effects, called the oxygen enhancement ratio (OER), is very important factor in radiotherapy since none produces such a dramatic effect and no other agent has such obvious practical implication. Although it is usually assumed that the dose distribution in a cell box is uniform, the absorbed dose to the tumor cells could be very different according to the locations of the cells within a cell box, which affects the cell survival curves. We have studied the inhomogeneous dose distribution in a cell box due to the scattering of x‐rays with the cover and side‐walls of cell box. Method and Materials: Three different sizes of cubical cell boxes, whose side lengths are 10, 15, 20 cm, were designed and irradiated by 6 and 15 MV x‐rays using Varian 2100CD linear accelerator. Results: The differences of the absorbed doses at the center between 10×10×10 cm3 box and 20×20×20 cm3 box were less than 2 % for 6 MV and 15 MV x‐ray irradiation, which indicates that the scattering effect depending on the size of cell box is not significant for the absolute absorbed dose at the center of box. However, the relative dose distribution within the cell box shows very different behavior revealing distinct heterogeneous dose distribution in a cell box. For example, the percentage showing more than 10 % dose difference within the cell box was ∼ 40 % for 20×20×20 cm3 box with 15 MV x‐ray irradiation. Conclusion: While the dose inhomogeneity for 15 MV x‐ray irradiation increases as the size of cell box increases, the dose inhomogeneity for 6 MV x‐ray doesn't show any size dependency. Our experimental evidence suggests that the dose inhomogeneity within the cell box is not negligible.

AB - Purpose: The ratio of hypoxic to aerated doses needed to achieve the same biological effects, called the oxygen enhancement ratio (OER), is very important factor in radiotherapy since none produces such a dramatic effect and no other agent has such obvious practical implication. Although it is usually assumed that the dose distribution in a cell box is uniform, the absorbed dose to the tumor cells could be very different according to the locations of the cells within a cell box, which affects the cell survival curves. We have studied the inhomogeneous dose distribution in a cell box due to the scattering of x‐rays with the cover and side‐walls of cell box. Method and Materials: Three different sizes of cubical cell boxes, whose side lengths are 10, 15, 20 cm, were designed and irradiated by 6 and 15 MV x‐rays using Varian 2100CD linear accelerator. Results: The differences of the absorbed doses at the center between 10×10×10 cm3 box and 20×20×20 cm3 box were less than 2 % for 6 MV and 15 MV x‐ray irradiation, which indicates that the scattering effect depending on the size of cell box is not significant for the absolute absorbed dose at the center of box. However, the relative dose distribution within the cell box shows very different behavior revealing distinct heterogeneous dose distribution in a cell box. For example, the percentage showing more than 10 % dose difference within the cell box was ∼ 40 % for 20×20×20 cm3 box with 15 MV x‐ray irradiation. Conclusion: While the dose inhomogeneity for 15 MV x‐ray irradiation increases as the size of cell box increases, the dose inhomogeneity for 6 MV x‐ray doesn't show any size dependency. Our experimental evidence suggests that the dose inhomogeneity within the cell box is not negligible.

UR - http://www.scopus.com/inward/record.url?scp=85024799589&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85024799589&partnerID=8YFLogxK

U2 - 10.1118/1.2241317

DO - 10.1118/1.2241317

M3 - Article

AN - SCOPUS:85024799589

VL - 33

SP - 2137

JO - Medical Physics

JF - Medical Physics

SN - 0094-2405

IS - 6

ER -