Suicidal ideation among postmenopausal women on hormone replacement therapy

The Korean National Health and Nutrition Examination Survey (KNHANES V) from 2010 to 2012

Ji Yoon Lee, Yong Kyu Park, Kyung-Hwan Cho, Seon Mee Kim, Youn Seon Choi, Do-Hoon Kim, Ga Eun Nam, Kyung Do Han, Yang-Hyun Kim

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Background Suicide is a major public health problem around the world. Some studies have found that hormone replacement therapy (HRT) is associated with depression in postmenopausal women. Depression is a well-known risk factor for suicide; therefore, we investigated the relationship between HRT and suicidal ideation in postmenopausal Korean women. Methods We included 2286 postmenopausal women with or without HRT from the Korean National Health and Nutrition Examination Survey 2010-2012. The use and duration of HRT and mental health status, including stress, depressive mood, and suicidal ideation and attempts, were assessed by self-report questionnaires. Results The proportion of participants with depressive mood and suicidal ideation was higher in the HRT group than the non-HRT group (all p values<0.05). As the duration of HRT increased, the percentage of participants with suicidal ideation increased (p for trend=0.006). After adjusting for all covariates, the odds ratio (95% confidence intervals) for suicidal ideation was 1.742 (1.223-2.482) in the women with HRT, compared to women without HRT. HRT duration longer than 10 years was associated with suicidal ideation (odds ratio=2.089 and 95% confidence intervals=1.069-4.084). Limitations The cross-sectional design, a possibility of incorrect answer about menopausal status, and no assessment of the type of HRT are the main limitations of this study. Conclusion Postmenopausal women receiving HRT, especially for more than 10 years, showed increased suicidal ideation compared with postmenopausal women without HRT. Physicians should pay attention to mood symptoms and suicidal ideation in postmenopausal women with HRT.

Original languageEnglish
Pages (from-to)214-219
Number of pages6
JournalJournal of Affective Disorders
Volume189
DOIs
Publication statusPublished - 2016 Jan 1

Fingerprint

Suicidal Ideation
Nutrition Surveys
Hormone Replacement Therapy
Suicide
Odds Ratio
Confidence Intervals
Depression
Group Psychotherapy
Self Report
Health Status
Mental Health

Keywords

  • Hormone replacement therapy
  • Korean National Health and Nutrition Examination Survey
  • Postmenopausal women
  • Suicidal ideation

ASJC Scopus subject areas

  • Clinical Psychology
  • Psychiatry and Mental health

Cite this

@article{4aff081b62e840faa0756b29cbb3687d,
title = "Suicidal ideation among postmenopausal women on hormone replacement therapy: The Korean National Health and Nutrition Examination Survey (KNHANES V) from 2010 to 2012",
abstract = "Background Suicide is a major public health problem around the world. Some studies have found that hormone replacement therapy (HRT) is associated with depression in postmenopausal women. Depression is a well-known risk factor for suicide; therefore, we investigated the relationship between HRT and suicidal ideation in postmenopausal Korean women. Methods We included 2286 postmenopausal women with or without HRT from the Korean National Health and Nutrition Examination Survey 2010-2012. The use and duration of HRT and mental health status, including stress, depressive mood, and suicidal ideation and attempts, were assessed by self-report questionnaires. Results The proportion of participants with depressive mood and suicidal ideation was higher in the HRT group than the non-HRT group (all p values<0.05). As the duration of HRT increased, the percentage of participants with suicidal ideation increased (p for trend=0.006). After adjusting for all covariates, the odds ratio (95{\%} confidence intervals) for suicidal ideation was 1.742 (1.223-2.482) in the women with HRT, compared to women without HRT. HRT duration longer than 10 years was associated with suicidal ideation (odds ratio=2.089 and 95{\%} confidence intervals=1.069-4.084). Limitations The cross-sectional design, a possibility of incorrect answer about menopausal status, and no assessment of the type of HRT are the main limitations of this study. Conclusion Postmenopausal women receiving HRT, especially for more than 10 years, showed increased suicidal ideation compared with postmenopausal women without HRT. Physicians should pay attention to mood symptoms and suicidal ideation in postmenopausal women with HRT.",
keywords = "Hormone replacement therapy, Korean National Health and Nutrition Examination Survey, Postmenopausal women, Suicidal ideation",
author = "Lee, {Ji Yoon} and Park, {Yong Kyu} and Kyung-Hwan Cho and Kim, {Seon Mee} and Choi, {Youn Seon} and Do-Hoon Kim and Nam, {Ga Eun} and Han, {Kyung Do} and Yang-Hyun Kim",
year = "2016",
month = "1",
day = "1",
doi = "10.1016/j.jad.2015.09.068",
language = "English",
volume = "189",
pages = "214--219",
journal = "Journal of Affective Disorders",
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TY - JOUR

T1 - Suicidal ideation among postmenopausal women on hormone replacement therapy

T2 - The Korean National Health and Nutrition Examination Survey (KNHANES V) from 2010 to 2012

AU - Lee, Ji Yoon

AU - Park, Yong Kyu

AU - Cho, Kyung-Hwan

AU - Kim, Seon Mee

AU - Choi, Youn Seon

AU - Kim, Do-Hoon

AU - Nam, Ga Eun

AU - Han, Kyung Do

AU - Kim, Yang-Hyun

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Background Suicide is a major public health problem around the world. Some studies have found that hormone replacement therapy (HRT) is associated with depression in postmenopausal women. Depression is a well-known risk factor for suicide; therefore, we investigated the relationship between HRT and suicidal ideation in postmenopausal Korean women. Methods We included 2286 postmenopausal women with or without HRT from the Korean National Health and Nutrition Examination Survey 2010-2012. The use and duration of HRT and mental health status, including stress, depressive mood, and suicidal ideation and attempts, were assessed by self-report questionnaires. Results The proportion of participants with depressive mood and suicidal ideation was higher in the HRT group than the non-HRT group (all p values<0.05). As the duration of HRT increased, the percentage of participants with suicidal ideation increased (p for trend=0.006). After adjusting for all covariates, the odds ratio (95% confidence intervals) for suicidal ideation was 1.742 (1.223-2.482) in the women with HRT, compared to women without HRT. HRT duration longer than 10 years was associated with suicidal ideation (odds ratio=2.089 and 95% confidence intervals=1.069-4.084). Limitations The cross-sectional design, a possibility of incorrect answer about menopausal status, and no assessment of the type of HRT are the main limitations of this study. Conclusion Postmenopausal women receiving HRT, especially for more than 10 years, showed increased suicidal ideation compared with postmenopausal women without HRT. Physicians should pay attention to mood symptoms and suicidal ideation in postmenopausal women with HRT.

AB - Background Suicide is a major public health problem around the world. Some studies have found that hormone replacement therapy (HRT) is associated with depression in postmenopausal women. Depression is a well-known risk factor for suicide; therefore, we investigated the relationship between HRT and suicidal ideation in postmenopausal Korean women. Methods We included 2286 postmenopausal women with or without HRT from the Korean National Health and Nutrition Examination Survey 2010-2012. The use and duration of HRT and mental health status, including stress, depressive mood, and suicidal ideation and attempts, were assessed by self-report questionnaires. Results The proportion of participants with depressive mood and suicidal ideation was higher in the HRT group than the non-HRT group (all p values<0.05). As the duration of HRT increased, the percentage of participants with suicidal ideation increased (p for trend=0.006). After adjusting for all covariates, the odds ratio (95% confidence intervals) for suicidal ideation was 1.742 (1.223-2.482) in the women with HRT, compared to women without HRT. HRT duration longer than 10 years was associated with suicidal ideation (odds ratio=2.089 and 95% confidence intervals=1.069-4.084). Limitations The cross-sectional design, a possibility of incorrect answer about menopausal status, and no assessment of the type of HRT are the main limitations of this study. Conclusion Postmenopausal women receiving HRT, especially for more than 10 years, showed increased suicidal ideation compared with postmenopausal women without HRT. Physicians should pay attention to mood symptoms and suicidal ideation in postmenopausal women with HRT.

KW - Hormone replacement therapy

KW - Korean National Health and Nutrition Examination Survey

KW - Postmenopausal women

KW - Suicidal ideation

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U2 - 10.1016/j.jad.2015.09.068

DO - 10.1016/j.jad.2015.09.068

M3 - Review article

VL - 189

SP - 214

EP - 219

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

ER -