Sulfonate chalcone as new class voltage-dependent K + channel blocker

Oleg V. Yarishkin, Hyung Won Ryu, Jae-Yong Park, Min Suk Yang, Seong Geun Hong, Ki Hun Park

Research output: Contribution to journalArticle

54 Citations (Scopus)

Abstract

Chalcone derivatives 1-17 were synthesized and their voltage-dependent K + channel inhibitory activities were investigated. The effective K + channel blockers were shown to be sulfonate chalcones 9-17, in which the sulfonyloxy group is placed on the A-ring. The 3′-(p-aminobenzene-sulfonylhydroxy)-4-hydroxychalcone 17 (IC 50 = 0.51 ± 0.05 μM) was the most potent K + channel blocker.

Original languageEnglish
Pages (from-to)137-140
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume18
Issue number1
DOIs
Publication statusPublished - 2008 Jan 1
Externally publishedYes

Keywords

  • Chalcone
  • Ion channel
  • K channel blocker
  • Potassium channel blocker
  • Sulfonate chalcone

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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