11C-methionine PET as a prognostic marker in patients with glioma: Comparison with 18F-FDG PET

Sungeun Kim, June Key Chung, So Hyang Im, Jae Min Jeong, Dong Soo Lee, Dong Gyu Kim, Hee Won Jung, Myung Chul Lee

Research output: Contribution to journalArticlepeer-review

144 Citations (Scopus)


Purpose: The purpose of this study was to compare the prognostic value of 11C-methionine (MET) and 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) in glioma patients. Methods: The study population comprised 47 patients with gliomas (19 glioblastoma, 28 others). Pretreatment magnetic resonance imaging, MET PET and FDG PET were performed within a time interval of 2 weeks in all patients. The uptake ratio and standard uptake values were calculated. Univariate and multivariate analyses were done to determine significant prognostic factors. Ki-67 index was measured by immunohistochemical staining, and compared with FDG and MET uptake in glioma. Results: Among the several clinicopathological prognostic factors, tumour pathology (glioblastoma or not), age (≥60 or <60 years), Karnofsky performance status (KPS) (≥70 or <70) and MET PET (higher uptake or not compared with normal cortex) were found to be significant predictors by univariate analysis. In multivariate analysis, tumour pathology, KPS and MET PET were identified as significant independent predictors. The Ki-67 proliferation index was significantly correlated with MET uptake (r=0.64), but not with FDG uptake. Conclusion: Compared with FDG PET in glioma, MET PET was an independent significant prognostic factor and MET uptake was correlated with cellular proliferation. MET PET may be a useful biological prognostic marker in glioma patients.

Original languageEnglish
Pages (from-to)52-59
Number of pages8
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number1
Publication statusPublished - 2005 Jan
Externally publishedYes


  • C-methionine
  • F-FDG
  • Malignant glioma
  • PET
  • Prognosis

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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