18F-FDG Uptake of Human Testis on PET/CT

Correlation with Age, Sex Hormones, and Vasectomy

Seung Hwan Moon, Jae Seon Eo, Jong Jin Lee, June Key Chung, Dong Soo Lee, Myung Chul Lee

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose: The purpose of this study was to evaluate glucose metabolism of normal human testis on 18F-FDG PET/CT and to assess possible correlations among age, the serum levels of sex hormones, and vasectomy. Methods: 18F-FDG PET/CT was performed in 66 normal healthy men (50.8 ± 13.6 years, range 22-81), and mean standard uptake values (SUV) of 18F-FDG in testis and adductor muscle were measured. Testis-muscle SUV ratios (T/M ratios) were calculated. Serum levels of total testosterone, free testosterone, estradiol, and of sex-hormone binding globulin (SHBG) were measured. We searched for correlations between T/M ratios and age and the serum concentrations of sex hormones. 18F-FDG PET/CT was also performed in 32 vasectomized men (55.7 ± 7.8 years, range 38-71) and 52 nonvasectomized men (55.4 ± 11.6 years, range 37-72). Mean SUVs of testis and adductor muscle were measured, and T/M ratios were calculated. Results: A significant age-related decline was found in T/M ratio (r = -0.509, p < 0.0001). Serum levels of total testosterone and free testosterone were also found to be positively correlated with T/M ratio (r = 0.427, p = 0.0003; r = 0.435, p = 0.0003, respectively). The mean SUV and T/M ratio of vasectomized men were significantly lower than those of nonvasectomized men (p < 0.0378 and p = 0.0001, respectively). Conclusions: Glucose metabolism in the testis in an adult population was found to be correlated with age, serum sex hormone level, and vasectomy history. These results indicate that testicular 18F-FDG uptake may have attributed to testicular function and testicular histology. Our findings may have important implications for the interpretation of testicular 18F-FDG uptake in the normal adult population.

Original languageEnglish
Pages (from-to)291-298
Number of pages8
JournalNuclear Medicine and Molecular Imaging
Volume45
Issue number4
DOIs
Publication statusPublished - 2011 Dec 1
Externally publishedYes

Fingerprint

Vasectomy
Fluorodeoxyglucose F18
Gonadal Steroid Hormones
Testis
Muscles
Testosterone
Serum
Glucose
Sex Hormone-Binding Globulin
Population
Estradiol
Histology
History

Keywords

  • F-FDG PET/CT
  • Glucose metabolism
  • SUV
  • Testis
  • Testosterone
  • Vasectomy

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

18F-FDG Uptake of Human Testis on PET/CT : Correlation with Age, Sex Hormones, and Vasectomy. / Moon, Seung Hwan; Eo, Jae Seon; Lee, Jong Jin; Chung, June Key; Lee, Dong Soo; Lee, Myung Chul.

In: Nuclear Medicine and Molecular Imaging, Vol. 45, No. 4, 01.12.2011, p. 291-298.

Research output: Contribution to journalArticle

Moon, Seung Hwan ; Eo, Jae Seon ; Lee, Jong Jin ; Chung, June Key ; Lee, Dong Soo ; Lee, Myung Chul. / 18F-FDG Uptake of Human Testis on PET/CT : Correlation with Age, Sex Hormones, and Vasectomy. In: Nuclear Medicine and Molecular Imaging. 2011 ; Vol. 45, No. 4. pp. 291-298.
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AU - Chung, June Key

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AU - Lee, Myung Chul

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