Abstract
Purpose: The purpose of this study was to evaluate glucose metabolism of normal human testis on 18F-FDG PET/CT and to assess possible correlations among age, the serum levels of sex hormones, and vasectomy. Methods: 18F-FDG PET/CT was performed in 66 normal healthy men (50.8 ± 13.6 years, range 22-81), and mean standard uptake values (SUV) of 18F-FDG in testis and adductor muscle were measured. Testis-muscle SUV ratios (T/M ratios) were calculated. Serum levels of total testosterone, free testosterone, estradiol, and of sex-hormone binding globulin (SHBG) were measured. We searched for correlations between T/M ratios and age and the serum concentrations of sex hormones. 18F-FDG PET/CT was also performed in 32 vasectomized men (55.7 ± 7.8 years, range 38-71) and 52 nonvasectomized men (55.4 ± 11.6 years, range 37-72). Mean SUVs of testis and adductor muscle were measured, and T/M ratios were calculated. Results: A significant age-related decline was found in T/M ratio (r = -0.509, p < 0.0001). Serum levels of total testosterone and free testosterone were also found to be positively correlated with T/M ratio (r = 0.427, p = 0.0003; r = 0.435, p = 0.0003, respectively). The mean SUV and T/M ratio of vasectomized men were significantly lower than those of nonvasectomized men (p < 0.0378 and p = 0.0001, respectively). Conclusions: Glucose metabolism in the testis in an adult population was found to be correlated with age, serum sex hormone level, and vasectomy history. These results indicate that testicular 18F-FDG uptake may have attributed to testicular function and testicular histology. Our findings may have important implications for the interpretation of testicular 18F-FDG uptake in the normal adult population.
| Original language | English |
|---|---|
| Pages (from-to) | 291-298 |
| Number of pages | 8 |
| Journal | Nuclear Medicine and Molecular Imaging |
| Volume | 45 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2011 Dec 1 |
| Externally published | Yes |
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Keywords
- F-FDG PET/CT
- Glucose metabolism
- SUV
- Testis
- Testosterone
- Vasectomy
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
Cite this
18F-FDG Uptake of Human Testis on PET/CT : Correlation with Age, Sex Hormones, and Vasectomy. / Moon, Seung Hwan; Eo, Jae Seon; Lee, Jong Jin; Chung, June Key; Lee, Dong Soo; Lee, Myung Chul.
In: Nuclear Medicine and Molecular Imaging, Vol. 45, No. 4, 01.12.2011, p. 291-298.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - 18F-FDG Uptake of Human Testis on PET/CT
T2 - Correlation with Age, Sex Hormones, and Vasectomy
AU - Moon, Seung Hwan
AU - Eo, Jae Seon
AU - Lee, Jong Jin
AU - Chung, June Key
AU - Lee, Dong Soo
AU - Lee, Myung Chul
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Purpose: The purpose of this study was to evaluate glucose metabolism of normal human testis on 18F-FDG PET/CT and to assess possible correlations among age, the serum levels of sex hormones, and vasectomy. Methods: 18F-FDG PET/CT was performed in 66 normal healthy men (50.8 ± 13.6 years, range 22-81), and mean standard uptake values (SUV) of 18F-FDG in testis and adductor muscle were measured. Testis-muscle SUV ratios (T/M ratios) were calculated. Serum levels of total testosterone, free testosterone, estradiol, and of sex-hormone binding globulin (SHBG) were measured. We searched for correlations between T/M ratios and age and the serum concentrations of sex hormones. 18F-FDG PET/CT was also performed in 32 vasectomized men (55.7 ± 7.8 years, range 38-71) and 52 nonvasectomized men (55.4 ± 11.6 years, range 37-72). Mean SUVs of testis and adductor muscle were measured, and T/M ratios were calculated. Results: A significant age-related decline was found in T/M ratio (r = -0.509, p < 0.0001). Serum levels of total testosterone and free testosterone were also found to be positively correlated with T/M ratio (r = 0.427, p = 0.0003; r = 0.435, p = 0.0003, respectively). The mean SUV and T/M ratio of vasectomized men were significantly lower than those of nonvasectomized men (p < 0.0378 and p = 0.0001, respectively). Conclusions: Glucose metabolism in the testis in an adult population was found to be correlated with age, serum sex hormone level, and vasectomy history. These results indicate that testicular 18F-FDG uptake may have attributed to testicular function and testicular histology. Our findings may have important implications for the interpretation of testicular 18F-FDG uptake in the normal adult population.
AB - Purpose: The purpose of this study was to evaluate glucose metabolism of normal human testis on 18F-FDG PET/CT and to assess possible correlations among age, the serum levels of sex hormones, and vasectomy. Methods: 18F-FDG PET/CT was performed in 66 normal healthy men (50.8 ± 13.6 years, range 22-81), and mean standard uptake values (SUV) of 18F-FDG in testis and adductor muscle were measured. Testis-muscle SUV ratios (T/M ratios) were calculated. Serum levels of total testosterone, free testosterone, estradiol, and of sex-hormone binding globulin (SHBG) were measured. We searched for correlations between T/M ratios and age and the serum concentrations of sex hormones. 18F-FDG PET/CT was also performed in 32 vasectomized men (55.7 ± 7.8 years, range 38-71) and 52 nonvasectomized men (55.4 ± 11.6 years, range 37-72). Mean SUVs of testis and adductor muscle were measured, and T/M ratios were calculated. Results: A significant age-related decline was found in T/M ratio (r = -0.509, p < 0.0001). Serum levels of total testosterone and free testosterone were also found to be positively correlated with T/M ratio (r = 0.427, p = 0.0003; r = 0.435, p = 0.0003, respectively). The mean SUV and T/M ratio of vasectomized men were significantly lower than those of nonvasectomized men (p < 0.0378 and p = 0.0001, respectively). Conclusions: Glucose metabolism in the testis in an adult population was found to be correlated with age, serum sex hormone level, and vasectomy history. These results indicate that testicular 18F-FDG uptake may have attributed to testicular function and testicular histology. Our findings may have important implications for the interpretation of testicular 18F-FDG uptake in the normal adult population.
KW - F-FDG PET/CT
KW - Glucose metabolism
KW - SUV
KW - Testis
KW - Testosterone
KW - Vasectomy
UR - http://www.scopus.com/inward/record.url?scp=82855161021&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=82855161021&partnerID=8YFLogxK
U2 - 10.1007/s13139-011-0108-6
DO - 10.1007/s13139-011-0108-6
M3 - Article
VL - 45
SP - 291
EP - 298
JO - Nuclear Medicine and Molecular Imaging
JF - Nuclear Medicine and Molecular Imaging
SN - 1869-3474
IS - 4
ER -