18F-THK5351 PET Positivity and Longitudinal Changes in Cognitive Function in β-Amyloid-Negative Amnestic Mild Cognitive Impairment

Min Young Chun, Jongmin Lee, Jee Hyang Jeong, Jee Hoon Roh, Seung Jun Oh, Minyoung Oh, Jungsu S. Oh, Jae Seung Kim, Seung Hwan Moon, Sook Young Woo, Young Ju Kim, Yeong Sim Choe, Hee Jin Kim, Duk L. Na, Hyemin Jang, Sang Won Seo

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: Neuroinflammation is considered an important pathway associated with several diseases that result in cognitive decline.18F-THK5351 positron emission tomography (PET) signals might indicate the presence of neuroinflammation, as well as Alzheimer’s disease-type tau aggregates. β-amyloid (Aβ)-negative (Aβ–) amnestic mild cognitive impairment (aMCI) may be associated with non-Alzheimer’s disease pathophysiology. Accordingly, we investigated associations between18F-THK5351 PET positivity and cognitive decline among Aβ– aMCI patients. Materials and Methods: The present study included 25 amyloid PET negative aMCI patients who underwent a minimum of two follow-up neuropsychological evaluations, including clinical dementia rating-sum of boxes (CDR-SOB). The patients were classified into two groups:18F-THK5351-positive and-negative groups. The present study used a linear mixed effects model to estimate the effects of18F-THK5351 PET positivity on cognitive prognosis among Aβ– aMCI patients. Results: Among the 25 Aβ– aMCI patients, 10 (40.0%) were18F-THK5351 positive. The patients in the18F-THK5351-positive group were older than those in the18F-THK5351-negative group (77.4±2.2 years vs. 70.0±5.5 years; p<0.001). There was no difference between the two groups with regard to the proportion of apolipoprotein E ε4 carriers. Interestingly, however, the CDR-SOB scores of the18F-THK5351-positive group deteriorated at a faster rate than those of the18F-THK5351-negative group (B=0.003, p=0.033). Conclusion: The results of the present study suggest that increased18F-THK5351 uptake might be a useful predictor of poor prognosis among Aβ– aMCI patients, which might be associated with increased neuroinflammation (ClinicalTrials.gov NCT02656498).

Original languageEnglish
Pages (from-to)259-264
Number of pages6
JournalYonsei medical journal
Volume63
Issue number3
DOIs
Publication statusPublished - 2022 Mar

Keywords

  • Amyloid
  • Inflammation
  • Mild cognitive impairment
  • Tau proteins
  • ‌Positron emission tomography

ASJC Scopus subject areas

  • Medicine(all)

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