Abstract
This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin-mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well-defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.
| Original language | English |
|---|---|
| Journal | Small |
| DOIs | |
| Publication status | Accepted/In press - 2018 Jan 1 |
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Keywords
- Microfluidics
- Perspiration
- Super absorbent polymer
- Sweat chloride
ASJC Scopus subject areas
- Biotechnology
- Biomaterials
- Engineering (miscellaneous)
Cite this
Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics. / Kim, Sung Bong; Zhang, Yi; Won, Sang Min; Bandodkar, Amay J.; Sekine, Yurina; Xue, Yeguang; Koo, Jahyun; Harshman, Sean W.; Martin, Jennifer A.; Park, Jeong Min; Ray, Tyler R.; Crawford, Kaitlyn E.; Lee, Kyu Tae; Choi, Jungil; Pitsch, Rhonda L.; Grigsby, Claude C.; Strang, Adam J.; Chen, Yu Yu; Xu, Shuai; Kim, Jeonghyun; Koh, Ahyeon; Ha, Jeong Sook; Huang, Yonggang; Kim, Seung Wook; Rogers, John A.
In: Small, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics
AU - Kim, Sung Bong
AU - Zhang, Yi
AU - Won, Sang Min
AU - Bandodkar, Amay J.
AU - Sekine, Yurina
AU - Xue, Yeguang
AU - Koo, Jahyun
AU - Harshman, Sean W.
AU - Martin, Jennifer A.
AU - Park, Jeong Min
AU - Ray, Tyler R.
AU - Crawford, Kaitlyn E.
AU - Lee, Kyu Tae
AU - Choi, Jungil
AU - Pitsch, Rhonda L.
AU - Grigsby, Claude C.
AU - Strang, Adam J.
AU - Chen, Yu Yu
AU - Xu, Shuai
AU - Kim, Jeonghyun
AU - Koh, Ahyeon
AU - Ha, Jeong Sook
AU - Huang, Yonggang
AU - Kim, Seung Wook
AU - Rogers, John A.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin-mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well-defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.
AB - This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin-mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well-defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.
KW - Microfluidics
KW - Perspiration
KW - Super absorbent polymer
KW - Sweat chloride
UR - http://www.scopus.com/inward/record.url?scp=85041286853&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041286853&partnerID=8YFLogxK
U2 - 10.1002/smll.201703334
DO - 10.1002/smll.201703334
M3 - Article
C2 - 29394467
AN - SCOPUS:85041286853
JO - Small
JF - Small
SN - 1613-6810
ER -