Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics

Sung Bong Kim; Yi Zhang; Sang Min Won; Amay J. Bandodkar; Yurina Sekine; Yeguang Xue; Jahyun Koo; Sean W. Harshman; Jennifer A. Martin; Jeong Min Park; Tyler R. Ray; Kaitlyn E. Crawford; Kyu Tae Lee; Jungil Choi; Rhonda L. Pitsch; Claude C. Grigsby; Adam J. Strang; Yu Yu Chen; Shuai Xu; Jeonghyun Kim; Ahyeon Koh; Jeong Sook Ha; Yonggang Huang; Seung Wook Kim; John A. Rogers

doi:10.1002/smll.201703334

Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics

Sung Bong Kim, Yi Zhang, Sang Min Won, Amay J. Bandodkar, Yurina Sekine, Yeguang Xue, Jahyun Koo, Sean W. Harshman, Jennifer A. Martin, Jeong Min Park, Tyler R. Ray, Kaitlyn E. Crawford, Kyu Tae Lee, Jungil Choi, Rhonda L. Pitsch, Claude C. Grigsby, Adam J. Strang, Yu Yu Chen, Shuai Xu, Jeonghyun KimAhyeon Koh, Jeong Sook Ha, Yonggang Huang, Seung Wook Kim, John A. Rogers

Department of Chemical and Biological Engineering

Research output: Contribution to journal › Article

35 Citations (Scopus)

Abstract

This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin-mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well-defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.

Original language	English
Journal	Small
DOIs	https://doi.org/10.1002/smll.201703334
Publication status	Accepted/In press - 2018 Jan 1

Keywords

Microfluidics
Perspiration
Super absorbent polymer
Sweat chloride

ASJC Scopus subject areas

Biotechnology
Biomaterials
Engineering (miscellaneous)

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10.1002/smll.201703334

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Kim, S. B., Zhang, Y., Won, S. M., Bandodkar, A. J., Sekine, Y., Xue, Y., Koo, J., Harshman, S. W., Martin, J. A., Park, J. M., Ray, T. R., Crawford, K. E., Lee, K. T., Choi, J., Pitsch, R. L., Grigsby, C. C., Strang, A. J., Chen, Y. Y., Xu, S., ... Rogers, J. A. (Accepted/In press). Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics. Small. https://doi.org/10.1002/smll.201703334

Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics. / Kim, Sung Bong; Zhang, Yi; Won, Sang Min; Bandodkar, Amay J.; Sekine, Yurina; Xue, Yeguang; Koo, Jahyun; Harshman, Sean W.; Martin, Jennifer A.; Park, Jeong Min; Ray, Tyler R.; Crawford, Kaitlyn E.; Lee, Kyu Tae; Choi, Jungil; Pitsch, Rhonda L.; Grigsby, Claude C.; Strang, Adam J.; Chen, Yu Yu; Xu, Shuai; Kim, Jeonghyun; Koh, Ahyeon; Ha, Jeong Sook; Huang, Yonggang; Kim, Seung Wook; Rogers, John A.

In: Small, 01.01.2018.

Research output: Contribution to journal › Article

Kim, SB, Zhang, Y, Won, SM, Bandodkar, AJ, Sekine, Y, Xue, Y, Koo, J, Harshman, SW, Martin, JA, Park, JM, Ray, TR, Crawford, KE, Lee, KT, Choi, J, Pitsch, RL, Grigsby, CC, Strang, AJ, Chen, YY, Xu, S, Kim, J, Koh, A, Ha, JS, Huang, Y, Kim, SW & Rogers, JA 2018, 'Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics', Small. https://doi.org/10.1002/smll.201703334

Kim, Sung Bong ; Zhang, Yi ; Won, Sang Min ; Bandodkar, Amay J. ; Sekine, Yurina ; Xue, Yeguang ; Koo, Jahyun ; Harshman, Sean W. ; Martin, Jennifer A. ; Park, Jeong Min ; Ray, Tyler R. ; Crawford, Kaitlyn E. ; Lee, Kyu Tae ; Choi, Jungil ; Pitsch, Rhonda L. ; Grigsby, Claude C. ; Strang, Adam J. ; Chen, Yu Yu ; Xu, Shuai ; Kim, Jeonghyun ; Koh, Ahyeon ; Ha, Jeong Sook ; Huang, Yonggang ; Kim, Seung Wook ; Rogers, John A. / Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics. In: Small. 2018.

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abstract = "This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin-mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well-defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.",

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AU - Xue, Yeguang

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AU - Strang, Adam J.

AU - Chen, Yu Yu

AU - Xu, Shuai

AU - Kim, Jeonghyun

AU - Koh, Ahyeon

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