Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics

Sung Bong Kim, Yi Zhang, Sang Min Won, Amay J. Bandodkar, Yurina Sekine, Yeguang Xue, Jahyun Koo, Sean W. Harshman, Jennifer A. Martin, Jeong Min Park, Tyler R. Ray, Kaitlyn E. Crawford, Kyu Tae Lee, Jungil Choi, Rhonda L. Pitsch, Claude C. Grigsby, Adam J. Strang, Yu Yu Chen, Shuai Xu, Jeonghyun KimAhyeon Koh, Jeong Sook Ha, Yonggang Huang, Seung Wook Kim, John A. Rogers

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

This paper introduces super absorbent polymer valves and colorimetric sensing reagents as enabling components of soft, skin-mounted microfluidic devices designed to capture, store, and chemically analyze sweat released from eccrine glands. The valving technology enables robust means for guiding the flow of sweat from an inlet location into a collection of isolated reservoirs, in a well-defined sequence. Analysis in these reservoirs involves a color responsive indicator of chloride concentration with a formulation tailored to offer stable operation with sensitivity optimized for the relevant physiological range. Evaluations on human subjects with comparisons against ex situ analysis illustrate the practical utility of these advances.

Original languageEnglish
JournalSmall
DOIs
Publication statusAccepted/In press - 2018 Jan 1

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Keywords

  • Microfluidics
  • Perspiration
  • Super absorbent polymer
  • Sweat chloride

ASJC Scopus subject areas

  • Biotechnology
  • Biomaterials
  • Engineering (miscellaneous)

Cite this

Kim, S. B., Zhang, Y., Won, S. M., Bandodkar, A. J., Sekine, Y., Xue, Y., Koo, J., Harshman, S. W., Martin, J. A., Park, J. M., Ray, T. R., Crawford, K. E., Lee, K. T., Choi, J., Pitsch, R. L., Grigsby, C. C., Strang, A. J., Chen, Y. Y., Xu, S., ... Rogers, J. A. (Accepted/In press). Super-Absorbent Polymer Valves and Colorimetric Chemistries for Time-Sequenced Discrete Sampling and Chloride Analysis of Sweat via Skin-Mounted Soft Microfluidics. Small. https://doi.org/10.1002/smll.201703334