Suppression of Th2-driven, allergen-induced airway inflammation by sauchinone

Hyun Jung Min, Hee Yeon Won, Young Choong Kim, Sang Hyun Sung, Mi Ran Byun, Jun Ha Hwang, Jeong-Ho Hong, Eun Sook Hwang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Sauchinone, a lignan compound isolated from the root of Saururus chinensis, has been recently demonstrated to exhibit anti-inflammatory activity via the suppression of NF-kB p65 activity in vitro. In an effort to evaluate the in vivo anti-inflammatory function of sauchinone, we have evaluated the effects of sauchinone on allergen-induced airway inflammation using a murine model of allergic asthma. We observed that marked eosinophilic and lymphocyte infiltration in the BAL fluid were suppressed to a significant degree by sauchinone, and that mucus-secreting goblet cell hyperplasia and collagen deposition in the airways were also ameliorated by administration of sauchinone treatment. Moreover, gene expression of the inflammatory cytokines, IL-13, and IL-5 and eotaxin in the lung, and IL-5 in the draining lymph node were significantly decreased in sauchinone-treated mice. We demonstrated that sauchinone repressed Th2 cell development in vitro and IL-4 production by Th2 cells, and also inhibited GATA-3-mediated IL-5 promoter activity in a dose-dependent manner. Collectively, sauchinone ameliorated allergen-induced airway inflammation, in part, by repressing GATA-3 activity for Th2 cell development, indicating the possible therapeutic potential of sauchinone in airway inflammatory diseases including allergic asthma and rhinitis.

Original languageEnglish
Pages (from-to)204-209
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume385
Issue number2
DOIs
Publication statusPublished - 2009 Jul 24

Fingerprint

Allergens
Inflammation
Th2 Cells
Interleukin-5
Saururaceae
Anti-Inflammatory Agents
Asthma
sauchinone
Dimercaprol
Lignans
Goblet Cells
Interleukin-13
Lymphocytes
NF-kappa B
Mucus
Infiltration
Gene expression
Interleukin-4
Hyperplasia
Collagen

Keywords

  • Airway inflammatory diseases
  • Allergen-induced airway inflammation
  • GATA-3
  • Sauchinone
  • Th2 cell development

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Cell Biology
  • Molecular Biology

Cite this

Min, H. J., Won, H. Y., Kim, Y. C., Sung, S. H., Byun, M. R., Hwang, J. H., ... Hwang, E. S. (2009). Suppression of Th2-driven, allergen-induced airway inflammation by sauchinone. Biochemical and Biophysical Research Communications, 385(2), 204-209. https://doi.org/10.1016/j.bbrc.2009.05.039

Suppression of Th2-driven, allergen-induced airway inflammation by sauchinone. / Min, Hyun Jung; Won, Hee Yeon; Kim, Young Choong; Sung, Sang Hyun; Byun, Mi Ran; Hwang, Jun Ha; Hong, Jeong-Ho; Hwang, Eun Sook.

In: Biochemical and Biophysical Research Communications, Vol. 385, No. 2, 24.07.2009, p. 204-209.

Research output: Contribution to journalArticle

Min, Hyun Jung ; Won, Hee Yeon ; Kim, Young Choong ; Sung, Sang Hyun ; Byun, Mi Ran ; Hwang, Jun Ha ; Hong, Jeong-Ho ; Hwang, Eun Sook. / Suppression of Th2-driven, allergen-induced airway inflammation by sauchinone. In: Biochemical and Biophysical Research Communications. 2009 ; Vol. 385, No. 2. pp. 204-209.
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