Suppression of Th2-driven, allergen-induced airway inflammation by sauchinone

Hyun Jung Min, Hee Yeon Won, Young Choong Kim, Sang Hyun Sung, Mi Ran Byun, Jun Ha Hwang, Jeong Ho Hong, Eun Sook Hwang

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Sauchinone, a lignan compound isolated from the root of Saururus chinensis, has been recently demonstrated to exhibit anti-inflammatory activity via the suppression of NF-kB p65 activity in vitro. In an effort to evaluate the in vivo anti-inflammatory function of sauchinone, we have evaluated the effects of sauchinone on allergen-induced airway inflammation using a murine model of allergic asthma. We observed that marked eosinophilic and lymphocyte infiltration in the BAL fluid were suppressed to a significant degree by sauchinone, and that mucus-secreting goblet cell hyperplasia and collagen deposition in the airways were also ameliorated by administration of sauchinone treatment. Moreover, gene expression of the inflammatory cytokines, IL-13, and IL-5 and eotaxin in the lung, and IL-5 in the draining lymph node were significantly decreased in sauchinone-treated mice. We demonstrated that sauchinone repressed Th2 cell development in vitro and IL-4 production by Th2 cells, and also inhibited GATA-3-mediated IL-5 promoter activity in a dose-dependent manner. Collectively, sauchinone ameliorated allergen-induced airway inflammation, in part, by repressing GATA-3 activity for Th2 cell development, indicating the possible therapeutic potential of sauchinone in airway inflammatory diseases including allergic asthma and rhinitis.

Original languageEnglish
Pages (from-to)204-209
Number of pages6
JournalBiochemical and biophysical research communications
Volume385
Issue number2
DOIs
Publication statusPublished - 2009 Jul 24

Keywords

  • Airway inflammatory diseases
  • Allergen-induced airway inflammation
  • GATA-3
  • Sauchinone
  • Th2 cell development

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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