Abstract
Ethanol has been found to induce ulcerative gastric lesion in humans. The present study investigated the in vivo protective effect of astaxanthin isolated from the Xanthophyllomyces dendrorhous mutant against ethanol-induced gastric mucosal injury in rats. The rats were treated with 80% ethanol for 3d after pretreatment with two doses of astaxanthin (5 and 25 mg/kg of body weight respectively) for 3d, while the control rats received only 80% ethanol for 3d. The oral administration of astaxanthin (5 and 25 mg/kg of body weight) showed significant protection against ethanol-induced gastric lesion and inhibited elevation of the lipid peroxide level in gastric mucosa. In addition, pretreatment with astaxanthin resulted in a significant increase in the activities of radical scavenging enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. A histologic examination clearly indicated that the acute gastric mucosal lesion induced by ethanol nearly disappeared after pretreatment with astaxanthin.
| Original language | English |
|---|---|
| Pages (from-to) | 1300-1305 |
| Number of pages | 6 |
| Journal | Bioscience, Biotechnology and Biochemistry |
| Volume | 69 |
| Issue number | 7 |
| DOIs | |
| Publication status | Published - 2005 Sep 1 |
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Keywords
- Anti-ulcer drug
- Astaxanthin
- Gastric mucosal injury
- Orogastric administration
- Xanthophyllomyces dendrorhous
ASJC Scopus subject areas
- Bioengineering
- Biotechnology
- Biochemistry
- Biochemistry, Genetics and Molecular Biology(all)
- Chemistry (miscellaneous)
- Applied Microbiology and Biotechnology
- Food Science
Cite this
Suppressive effect of astaxanthin isolated from the Xanthophyllomyces dendrorhous mutant on ethanol-induced gastric mucosal injury in rats. / Kim, Jeong Hwan; Choi, Seok Keun; Choi, Sang-Yun; Kim, Han Kyeom; Chang, Hyo-Ihl.
In: Bioscience, Biotechnology and Biochemistry, Vol. 69, No. 7, 01.09.2005, p. 1300-1305.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Suppressive effect of astaxanthin isolated from the Xanthophyllomyces dendrorhous mutant on ethanol-induced gastric mucosal injury in rats
AU - Kim, Jeong Hwan
AU - Choi, Seok Keun
AU - Choi, Sang-Yun
AU - Kim, Han Kyeom
AU - Chang, Hyo-Ihl
PY - 2005/9/1
Y1 - 2005/9/1
N2 - Ethanol has been found to induce ulcerative gastric lesion in humans. The present study investigated the in vivo protective effect of astaxanthin isolated from the Xanthophyllomyces dendrorhous mutant against ethanol-induced gastric mucosal injury in rats. The rats were treated with 80% ethanol for 3d after pretreatment with two doses of astaxanthin (5 and 25 mg/kg of body weight respectively) for 3d, while the control rats received only 80% ethanol for 3d. The oral administration of astaxanthin (5 and 25 mg/kg of body weight) showed significant protection against ethanol-induced gastric lesion and inhibited elevation of the lipid peroxide level in gastric mucosa. In addition, pretreatment with astaxanthin resulted in a significant increase in the activities of radical scavenging enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. A histologic examination clearly indicated that the acute gastric mucosal lesion induced by ethanol nearly disappeared after pretreatment with astaxanthin.
AB - Ethanol has been found to induce ulcerative gastric lesion in humans. The present study investigated the in vivo protective effect of astaxanthin isolated from the Xanthophyllomyces dendrorhous mutant against ethanol-induced gastric mucosal injury in rats. The rats were treated with 80% ethanol for 3d after pretreatment with two doses of astaxanthin (5 and 25 mg/kg of body weight respectively) for 3d, while the control rats received only 80% ethanol for 3d. The oral administration of astaxanthin (5 and 25 mg/kg of body weight) showed significant protection against ethanol-induced gastric lesion and inhibited elevation of the lipid peroxide level in gastric mucosa. In addition, pretreatment with astaxanthin resulted in a significant increase in the activities of radical scavenging enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. A histologic examination clearly indicated that the acute gastric mucosal lesion induced by ethanol nearly disappeared after pretreatment with astaxanthin.
KW - Anti-ulcer drug
KW - Astaxanthin
KW - Gastric mucosal injury
KW - Orogastric administration
KW - Xanthophyllomyces dendrorhous
UR - http://www.scopus.com/inward/record.url?scp=23944490198&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=23944490198&partnerID=8YFLogxK
U2 - 10.1271/bbb.69.1300
DO - 10.1271/bbb.69.1300
M3 - Article
C2 - 16041134
AN - SCOPUS:23944490198
VL - 69
SP - 1300
EP - 1305
JO - Bioscience, Biotechnology and Biochemistry
JF - Bioscience, Biotechnology and Biochemistry
SN - 0916-8451
IS - 7
ER -